Erythropoietin and Anemia Treatment

Epo and hypoxia accelerate a pattern of gradual cell cycle shortening in BFU-e and CFU-e erythroid progenitors in vivo

Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors

The paper shows that deleting EPO in the forebrain of mice leads to increased expression of EPOR and EphB4, which may explain the lack of cognitive deficits in these mutants.

Erythropoietin-dependent Acquisition of CD71hiCD105hi Phenotype within CD235a- Early Erythroid Progenitors

This study identifies an Epo-dependent CFU-E subtype, lateC, characterized by CD71hiCD105hi phenotype and its role in erythropoiesis.

Transgenic augmentation of erythroferrone in mice ameliorates anemia in adenine-induced chronic kidney disease

This study shows that increasing erythroferrone in mice with CKD improves anemia by mobilizing iron and raising hemoglobin levels without worsening kidney function or inflammation.

Itaconate promotes the differentiation of murine stress erythroid progenitors by increasing Nrf2 activity.

The paper shows itaconate promotes differentiation of stress erythroid progenitors by increasing Nrf2 activity through anti-inflammatory signaling.

Rational design of selective bispecific EPO-R/CD131 agonists

The paper designs bispecific agonists targeting EPO-R/CD131 to selectively activate signaling without engaging EPO-R/EPO-R, validated through structural modeling and functional assays.

Session duration affects the magnitude of post-exercise hypervolemia but not the erythropoietin response to acute high-intensity interval exercise

Epo-IGF1R crosstalk expands stress-specific progenitors in regenerative erythropoiesis and myeloproliferative neoplasm

The paper identifies a stress-specific erythroid progenitor population that links regenerative erythropoiesis to pathogenic erythrocytosis through Epo-IGF1R crosstalk.

Rational engineering of an erythropoietin fusion protein to treat hypoxia

This paper describes the design of a modified erythropoietin fusion protein that promotes red blood cell production and neuroprotection without causing thrombosis.

Rational Design of a Bifunctional AND-Gate Ligand to Modulate Cell-Cell Interactions

The paper designs a bifunctional AND-gate ligand to modulate cell-cell interactions by avoiding thrombosis and RBC adhesion.