Erythropoietin and Anemia Treatment

Evaluation of Retinal Safety of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors

This study evaluates the effects of five HIF-PH inhibitors on Vegfa expression in the retina and other tissues of mice, finding differential regulation across tissues and suggesting retinal VEGF upregulation as a safety concern.

Erythropoietin Mediates Glycerophospholipid Remodeling During Human Early Erythropoiesis

This study identifies erythropoietin's role in regulating glycerophospholipid metabolism during human erythropoiesis using single-cell transcriptomics and lipidomics.

Epo and hypoxia accelerate a pattern of gradual cell cycle shortening in BFU-e and CFU-e erythroid progenitors in vivo

Using AI-MIDD for Mechanistic Erythropoietin Modeling: A Digital-Twin Framework for Optimizing ESA Therapies

The paper develops an AI-MIDD-QSP digital-twin framework to optimize ESA therapies by integrating mechanistic models of erythropoiesis and identifying dose-sparing strategies.

Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors

The paper shows that deleting EPO in the forebrain of mice leads to increased expression of EPOR and EphB4, which may explain the lack of cognitive deficits in these mutants.

Erythropoietin-dependent Acquisition of CD71hiCD105hi Phenotype within CD235a- Early Erythroid Progenitors

This study identifies an Epo-dependent CFU-E subtype, lateC, characterized by CD71hiCD105hi phenotype and its role in erythropoiesis.

Transgenic augmentation of erythroferrone in mice ameliorates anemia in adenine-induced chronic kidney disease

This study shows that increasing erythroferrone in mice with CKD improves anemia by mobilizing iron and raising hemoglobin levels without worsening kidney function or inflammation.

Itaconate promotes the differentiation of murine stress erythroid progenitors by increasing Nrf2 activity.

The paper shows itaconate promotes differentiation of stress erythroid progenitors by increasing Nrf2 activity through anti-inflammatory signaling.

Rational design of selective bispecific EPO-R/CD131 agonists

The paper designs bispecific agonists targeting EPO-R/CD131 to selectively activate signaling without engaging EPO-R/EPO-R, validated through structural modeling and functional assays.

Session duration affects the magnitude of post-exercise hypervolemia but not the erythropoietin response to acute high-intensity interval exercise

IL-17A primes an early progenitor compartment to tune the erythropoietic feedback circuit

This study shows IL-17A enhances erythropoietic response to hypoxia by sensitizing progenitors to erythropoietin, balancing reactivity and steady-state burden.

Erythropoietin single nucleotide polymorphisms are associated with anemia and dyslipidemia in a cardiovascular disease population

The paper identifies associations between EPO SNPs and anemia, dyslipidemia, and hypertension in cardiovascular disease patients using genotyping and clinical outcome analysis.

Preclinical study of the human recombinant Erythropoietin (GBPD002) compared with Eprex

This study compares the safety and toxicity of GBPD002 and Eprex(R), two recombinant human erythropoietins, in rats, finding similar toxicological profiles and no significant differences.

Erythropoietin production in embryonic neural cells is controlled by hypoxia-inducible factors and histone deacetylases in an undifferentiated state

This study identifies hypoxia-inducible factors and histone deacetylases as regulators of EPO production in embryonic neural cells under hypoxic conditions.

Epo-IGF1R crosstalk expands stress-specific progenitors in regenerative erythropoiesis and myeloproliferative neoplasm

The paper identifies a stress-specific erythroid progenitor population that links regenerative erythropoiesis to pathogenic erythrocytosis through Epo-IGF1R crosstalk.

Rational engineering of an erythropoietin fusion protein to treat hypoxia

This paper describes the design of a modified erythropoietin fusion protein that promotes red blood cell production and neuroprotection without causing thrombosis.

The Erythropoietin Receptor Stimulates Rapid Cycling and Formation of Larger Red Cells During Mouse and Human Erythropoiesis

This study shows that EpoR signaling accelerates cell cycling and increases red cell size in mouse and human erythropoiesis, independent of HRI and not due to reticulocyte increase.

Hypoxia pathway proteins regulate the synthesis and release of epinephrine in the mouse adrenal gland

This study shows that PHD2-HIF2 pathway regulates epinephrine synthesis and release in mouse adrenal glands, linking hypoxia signaling to catecholamine production and systemic glucose levels.

Rational Design of a Bifunctional AND-Gate Ligand to Modulate Cell-Cell Interactions

The paper designs a bifunctional AND-gate ligand to modulate cell-cell interactions by avoiding thrombosis and RBC adhesion.

Angiocrine factors from HUVECs amplify erythroid cells

This study identifies that HUVECs amplify erythroid cells through secreted angiocrine factors by maintaining their undifferentiated state and activating ERK signaling.