Kawasaki Disease and Coronary Complications

Spatial profiling of Kawasaki disease cardiac inflammation identifies STING as a therapeutic target

This study identifies STING as a therapeutic target for Kawasaki disease by analyzing spatial immune architecture in cardiac inflammation.

The IL-1β - BHLHE40 Axis in the Pathogenesis of Kawasaki Disease: Insights from Cell-Type-Specific Expression Analysis

This study identifies the IL-1β-BHLHE40 axis as a potential driver of Kawasaki disease through integrated single-cell and bulk transcriptomic analysis of human and murine models.

Single-cell Landscape of T Cell Heterogeneity in Kawasaki Disease: STAT3/JAK Axis Regulates the Lineage Differentiation Bias of Th17 Cells

The paper uses scRNA-seq to analyze T-cell subtypes in Kawasaki disease, identifying a Th17 differentiation bias regulated by the STAT3/JAK axis during acute inflammation.

Circulating miR-10b-5p drives Kawasaki vasculitis through endothelial reprogramming and nominates CXCL8 as an early diagnostic biomarker

This study identifies miR-10b-5p as a driver of Kawasaki disease vasculitis through endothelial reprogramming and shows CXCL8 as an early diagnostic biomarker.

Minimal Correlation but Complementary Diagnostic Utility for Plasma Cell-free RNA and Proteins

The paper compares plasma cell-free RNA and protein levels in children with inflammatory diseases, finding minimal correlation but similar diagnostic utility for distinguishing Kawasaki Disease from MIS-C.

Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Autophagy and Mitophagy

This study shows that SIRT1 activation reduces vasculitis severity in a murine model of Kawasaki disease by enhancing autophagy and mitophagy.

Delineation of Single-cell Altas Provides New Insights for Development of Coronary Artery Lesions in Kawasaki Disease: Bad and Good Signaling Molecules

This study uses single-cell RNA sequencing to identify dysregulated signaling molecules in Kawasaki Disease patients with and without coronary artery lesions.

The intestinal microbiota contributes to the development of immune-mediated cardiovascular inflammation and vasculitis in mice.

This study shows that gut microbiota depletion reduces cardiovascular inflammation in a mouse model of Kawasaki disease, and specific bacteria or their metabolites can alleviate vasculitis by improving gut barrier function.

Single-cell RNA-seq reveals altered plasma cell subsets and decreased cytotoxicity of NK cells in patients with Kawasaki diseas

This study uses scRNA-seq to analyze PBMCs in KD patients and healthy controls, identifying altered B cell subsets and reduced NK cell cytotoxicity.

Vasoactive Endothelial Growth Factor and Heat Shock Protein Gene Expression Response in Kawasaki Disease Associated Coronary Arteritis

This study identifies upregulated VEGF and HSP genes in Kawasaki Disease coronary artery inflammation and suggests their potential role in pathogenesis.

Genomic and phenotypic characterization of Multisystem Inflammatory Syndrome in Children (MIS-C): a prospective multicenter study from the Middle East

This study identifies rare genetic variants in MIS-C patients from the Middle East, linking them to disease onset and treatment resistance.

Kawasaki Disease patient stratification and pathway analysis based on host transcriptomic and proteomic profiles

This study stratifies Kawasaki Disease patients using transcriptomic and proteomic profiles, finding KD responses resemble bacterial infections but with distinct features suggesting alternative triggers.

The rs6505162 C>A polymorphism in the miRNA-423 gene exhibits a protective element of coronary artery in a southern Chinese population with Kawasaki disease

The paper investigates the association of miRNA-423 rs6505162 polymorphism with Kawasaki disease susceptibility and coronary artery lesions in a southern Chinese population.