Planarian Biology and Electrostimulation

This study investigates the relationship between embryonic development and regeneration in the acoel Hofstenia miamia, finding shared gene regulatory regions and distinct wound response dynamics.

The paper uses multiplex single-cell transcriptomics to study serotonergic neuron function in planarians, revealing widespread effects on diverse cell types and suggesting glial-like roles for parenchymal cells.

The paper describes a new Schmidtea species from Romania based on morphological and reproductive characteristics distinguishing it from known species.

This study examines how barium exposure affects planaria embryonic development, causing various axis abnormalities and congenital anomalies.

This study examines how age affects germ cell regeneration and sexual maturation in Platynereis dumerilii, finding that older worms regenerate faster and mature earlier despite higher regeneration costs.

This study quantifies epidermal cell turnover in planarians, revealing basal cell extrusion and intestinal digestion as mechanisms for cell removal.

The paper identifies a molecular mechanism for positional memory in limb regeneration, showing that posterior identity is encoded by Hand2 and can be reprogrammed through Shh signaling.

This study identifies PCP pathway components, pk-1 and dgo-1, as essential for anterior and posterior regeneration in Hofstenia miamia, with pk-1 affecting muscle organization and gene expression in tail fragments.

The paper investigates Wnt and Hedgehog signaling in tapeworm segmentation, finding that segments form through secondary AP axes linked to neuromuscular systems and regeneration mechanisms.

This study shows antibiotic treatment alters planarian behavior and withdrawal response to nicotine, suggesting microbiome changes affect motility and addictive behaviors.

The paper identifies key genes involved in regeneration in axolotl limbs by comparing transcriptomic data from juvenile and aged axolotls.

The paper investigates limb regeneration in ladybird beetles, finding that blastema formation is essential for regeneration, as amputation without blastema cells prevents limb redevelopment.

This study identifies Regeneration Initiating Cells (RICs) in Xenopus laevis tail regeneration using single cell and spatial transcriptomics, showing their role in initiating regeneration by modifying the extracellular matrix.

This study identifies Egr-2 as a regulator of intestinal remodeling and pharynx regeneration in planarians, showing its role in midline patterning and tissue integration.

This paper replicates and refutes a claim that dietary supplements induce leg regeneration in Drosophila, finding no evidence of regeneration or regeneration-like structures.

PLANAtools provides an interactive repository for analyzing planarian gene expression data from over 160 studies, enabling users to generate plots and annotations without requiring advanced computational expertise.

The paper identifies a muscle midline signaling center regulated by dorsoventral Netrins and Bambi-2 in planarians, which controls blastema formation during regeneration.

The paper uses high-throughput expression profiling and RNAi screening to identify novel regulators of planarian neoblast stem cells.

This study identifies two fibrillarin homologs in planarians and shows their distinct roles in cell lineage development and tissue regeneration.

This study shows that reactive oxygen species (ROS) signaling differentially controls wound healing and regeneration in planarians by regulating distinct downstream targets.

The paper identifies dynamic stem cell microenvironments in planarians that support regeneration by associating with diverse cell types.

The paper characterizes stem cell dynamics and heterogeneity in the acoel Hofstenia miamia using single-cell transcriptomics, revealing lineage-primed neoblast subpopulations and their response to regeneration.

The paper investigates how variable Shh and Fgf8 positioning in axolotl limb blastemas ensures consistent limb morphogenesis across different sizes.

The paper introduces a new fixation protocol for immunohistology and in situ hybridization in planarians that preserves tissue structure and allows for successful signal development.

This study shows that Pde4b regulates cellular differentiation during limb regeneration in urodele amphibians by modulating B2FF-induced plasticity in dermal fibroblasts.

This study investigates memory retention and transfer of addictive behavior in planaria, finding that addiction persists in both brain-containing and brainless posterior segments.

This study shows that m6A-mediated cell-cell communication is essential for planarian regeneration, as disrupting m6A methyltransferase leads to regeneration failure.

The paper generates a transgenic axolotl line expressing FUCCI to study cell cycle dynamics during tissue regeneration.

This study identifies DDX24 as essential for planarian head regeneration by regulating muscle organization, pole specification, and Wnt signaling.

This study shows that ERK inhibition delays regeneration in headless planarians, but headless animals can later remodel to regain a single-headed morphology through Wnt/β-catenin signaling.