Planarian Biology and Electrostimulation

Limb-localized induction of regeneration reshapes brain and amputation-site transcriptional states in adult Xenopus laevis

This study examines how limb regeneration in Xenopus laevis affects brain and amputation-site gene expression, identifying changes in metabolic and immune pathways and cross-species similarities in regenerative responses.

Flavins in Focus: Vitamin B2 as a Metabolic Keystone for Neuronal Repair in Regenerating Planarians

This study identifies flavin-rich cells essential for neuronal repair in regenerating planarians, showing their role in spatially organizing vitamin B2 metabolism during tissue regeneration.

Syntaxin-1 and syntaxin binding protein 1-1 are required for planarian behavior and brain regeneration

This study shows that syntaxin-1 and syntaxin-binding protein 1-1 are essential for planarian locomotion and brain regeneration, suggesting their role in synaptogenesis during neural repair.

Neuropeptide Signaling Promotes Stem-Cell Driven Regeneration in Planarians

This study identifies neuropeptide-processing enzymes and genes that promote regeneration and stem cell function in planarians.

Cell cycle exit is required for differentiation and cell fate diversification but not neoblast specialisation in planarians

This study shows cell cycle exit is necessary for terminal differentiation but not neoblast specialization in planarians, with lineage commitment occurring in cycling neoblasts.

DDR and TMEM132 genes control progenitor targeting and regenerative assembly of the planarian eye

The paper identifies DDR and TMEM132 genes as regulators of progenitor targeting and regenerative assembly in planarian eye regeneration through scRNA-seq and RNAi screening.

Adaptive immunity is dispensable for salamander appendage regeneration

Rag1-knockout newts lacking adaptive immunity regenerate larval limbs, tails and adult limbs without overt gross differences from controls; newt blastema tolerates allografts, and axolotl regenerating limbs show immunosuppressive transcriptional shifts.

Injury size regulates glucose allocation locally and systemically during vertebrate tissue regeneration

This study shows that injury size affects glucose allocation during tail regeneration in axolotls, with larger injuries leading to increased local and systemic glucose uptake.

Multi-omic characterization of axolotl perilymph-cerebrospinal fluid reveals shifts in composition during limb regeneration

This study characterizes axolotl perilymph-cerebrospinal fluid (P-CSF) during limb regeneration, identifying proteomic and metabolomic changes associated with amputation.

Ephrin Signaling Patterns Sensory Neurons During Tissue Homeostasis in Planarians

This study investigates Ephrin signaling's role in neural patterning during planarian tissue homeostasis, finding that EphR1 and ephrin-1 inhibition leads to ectopic mechanosensory neuron markers.

Trained Planaria Retain Memories Through Head Regeneration: A Model System for Insights into Non-Neural Memory and Neurodegenerative Diseases

Planarians trained to associate light with food kept their light preference after decapitation and 14-day head regeneration (7.65 min after vs 6.87 min before, out of 10; 10 worms).

Excessive feeding induces development of a colony-like body plan in paratomous flatworms

This study shows that excessive feeding in flatworms leads to the formation of colony-like body plans through changes in growth rates, without requiring new developmental programs or adaptive benefits.

An injury-responsive bHLH is required for regenerative responses following mechanical injury in adult Schistosoma mansoni

This study identifies an injury-responsive bHLH transcription factor essential for regenerative responses to mechanical injury in adult Schistosoma mansoni.

Divergent evolution of the Wnt signaling system in flatworms

This study investigates the evolution of Wnt signaling in flatworms, revealing gene losses and expression divergence that inform the evolutionary origins of regeneration.

Transcriptional Profiling of Planarian Regeneration Habituating to Physiological Stressor Reveals Individual and Collective Dynamics

The paper investigates transcriptional responses of planarians to BaCl2 stress, showing how regeneration history and social environment influence gene expression.

The CoP Assay: A Robust Method for Quantitative Assessment of Food Intake in the Planarian Dugesia japonica

The paper introduces the CoP assay to quantify food intake in planarians, showing they regulate consumption based on diet quality and exhibit satiety after partial ingestion.

Lack of specificity of planarian progenitor responses to injury in regeneration

This study shows planarian stem cells respond generically to injury, not specifically to the missing tissue, with varied incorporation into different tissues.

Failure to classically condition planarian flatworms

This study attempts to replicate classical conditioning in planarians but fails to find evidence of learning, suggesting historic protocols may be unsuitable for these species.

Life-cycle trajectory inference links temperature-gated progenitors to reproductive fate

The paper uses single-cell transcriptomics to infer life-cycle trajectories in planarians, showing how temperature gates stem cell fate to determine reproductive strategies.

A PCTAIRE family kinase regulates eye and brain size in freshwater planarians

This study identifies Smed-pctk-1 as a regulator of eye and brain size in planarians through functional analyses and behavioral assays.

Axolotl tail regeneration emerges during a defined embryonic window

The paper identifies a defined embryonic window in axolotls during which tail regeneration capacity develops, showing that regenerative competence can be acquired and is distinct from other vertebrates.

Sustained immune activation suppresses planarian regeneration

This study shows that sustained immune activation suppresses planarian regeneration by delaying regenerative progression and causing tissue lysis.

Adult regenerative defects arise from discordant scaling of signal dependent growth and patterning

The paper investigates how scaling of signaling pathways affects adult organ regeneration, finding that mismatched scaling of SHH and Wnt9a signaling prevents digit regeneration in large blastemas.

The nail mesenchyme creates a regeneration-specific ligand environment that orchestrates mammalian regeneration versus fibrotic wound healing

The paper identifies the nail mesenchyme's role in creating a BMP-rich ligand environment that drives regeneration over fibrosis in digit tip regeneration.

Adaptive immunity is dispensable for appendage regeneration in highly regenerative vertebrates

This study shows that adaptive immune cells are not required for appendage regeneration in axolotls and zebrafish, with regeneration proceeding normally despite the absence of mature T and B cells.

Hidden regenerative state in planarians: A geometric model of bioelectric memory using Tangential Action Spaces

The paper develops a geometric model of bioelectric memory in planarians using Tangential Action Spaces to predict regenerative state persistence and re-challenge outcomes.

Canonical mTOR signaling supports complete fin regeneration

This study shows that canonical mTOR signaling supports fin regeneration in Polypterus senegalus, challenging the idea that hypersensitive mTOR is required for complex appendage regeneration.

Model recapitulates regenerative limb blastema formation through local softening of the wounded epithelium

The paper develops a hybrid agent-based model to simulate limb blastema formation, identifying epithelial softening and Wnt signaling as key factors in regeneration.

Two axolotl-adapted cell-ablation platforms reveal macrophage-dependent processes essential for spinal-cord and skeletal regeneration

This paper develops and compares two cell-ablation systems in axolotls to study macrophage roles in regeneration, finding macrophages are essential for skeletal and nervous system repair.

Activin/TGF-beta signaling levels coordinate whole-body regeneration with genotoxic stress in Schmidtea mediterranea

The paper shows that activin/TGF-beta signaling inhibits regeneration after radiation in planarians, but its depletion restores regeneration by increasing stem cell proliferation despite DNA damage.