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This study identifies conserved Obg-type GTPases that support protein synthesis during physiological ribosomal pauses across domains of life.

This paper introduces STRATA, a framework that models interactions between lipid nanoparticle components and their ratios to improve prediction of transfection efficiency.

This study uses vT-ESI nMS to analyze how temperature-dependent changes in protein and solution dynamics affect ligand-binding thermodynamics in multiligand protein complexes.

The paper identifies two classes of nanobodies that inhibit Cif, an epoxide hydrolase from Pseudomonas aeruginosa, through distinct structural strategies targeting a shared epitope.

The paper investigates whether glycogen phosphorylase (GP) can be an insecticidal target in Plutella xylostella by evaluating the effects of GP inhibitors and showing that metabolic compensation via gluconeogenesis prevents insecticidal activity.

The paper presents cryo-EM structures of mitochondrial transcription initiation complexes, showing how TFAM and PolRMT interact with upstream DNA to regulate transcription initiation and specificity.

This study identifies and characterizes ferredoxin isoforms in Synechocystis sp. PCC 6803, revealing their redox properties and functional roles in electron transfer under varying environmental conditions.

This study uses cryoEM to reveal MgATP/MgADP-dependent conformational changes and IDR organization in vascular KATP channels.

This paper identifies sodium hypochlorite as an endogenous activator of IDO1, revealing a hypohalous acid-dependent catalytic mechanism for L-Trp oxidation.

This study identifies a non-transferable NLS in pSTAT1 that requires importin 5, Ran-GTP, and CAS for nuclear translocation and release, revealing a novel mechanism for cytokine-induced STAT1 signaling.

GraPPI develops a self-supervised graph encoder for protein-protein interaction modeling, achieving high performance in binding interface prediction and affinity prediction.

The paper determines the structure of PTDSS2 from Equus caballus in complex with PE or serine substrates, revealing substrate binding sites and PLD activity.

This study modifies de novo α-helical barrel biocatalysts using deep learning and computational methods to improve solubility and catalytic performance while maintaining structural stability.

This study reconstitutes transcription through the +1 nucleosome using purified yeast factors and finds that SAGA, Mediator, and TFIIH coordinate to overcome nucleosome barriers and regulate transcription initiation.

This study investigates how proton-coupled electron transfer and hydrogen bonding modulate radical propagation in proteins, using cytochrome c peroxidase and Zn-porphyrin variants as models.

This study shows β-arrestin1 directly binds Gαs to sustain endosomal GPCR signaling by stabilizing Gs in a signaling-competent state.

The paper develops an optimized targeted metabolomics workflow for analyzing central carbon metabolism intermediates in algae and plants with high sensitivity and accuracy.

This study identifies how diverse Llps inhibit the BAM complex by β-signal mimicry, revealing structural and functional mechanisms across Pseudomonas species.

This study uses SPLAT-TR to analyze proteome changes in ER stress, revealing distinct temporal phases of protein translocation, clearance, and degradation in different organelles.

The paper establishes a high-throughput screening dataset of small-molecule inhibitors across nine human DNA glycosylases, identifying previously unreported inhibitors and making data publicly available.