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This study identifies how TC-2559, a super-agonist, modulates the high sensitivity nicotinic acetylcholine receptor through both orthosteric and allosteric binding sites, enhancing channel opening.

This study investigates Mn-sensing riboswitches in E. coli, revealing how structural differences in their aptamers affect their response to Mn and pH.

This paper introduces a method using molecular dynamics simulations to predict water positions in cryo-EM maps by analyzing excess chemical potential, showing high agreement with experimental data.

The paper reports experimental data on six single-point mutants of β-glucosidase B from Paenibacillus polymyxa, analyzing their kinetic and thermal stability to improve computational enzyme modeling.

This study shows that type-B VanS from VRE directly interacts with vancomycin, activating its autokinase activity and confirming a direct sensing mechanism for VanS.

This study identifies SlNAP2 as a NAC transcription factor that promotes tomato fruit ripening by directly binding the ACS2 promoter and interacting with EIL3 to enhance ethylene signaling.

This study identifies milk lactalbumin-derived peptides that disrupt tau aggregation in Alzheimer's disease by altering PHF core structure and blocking subunit addition.

The paper identifies and validates a new inhibitor, B2, of PFKFB2 kinase activity through enzymatic assays and metabolic profiling in A-498 cells.

This paper designs and purifies a soluble form of ABCA4, a membrane transporter critical for vision, which maintains enzymatic activity without detergent-based purification.

This study shows that helicity and membrane permeabilization are not universal requirements for cathelicidin-mediated killing of gram-negative bacteria, and identifies lead compounds with improved selectivity.

This study shows Rpn11 acts as an allosteric ubiquitin sensor in the proteasome, enhancing substrate degradation by stabilizing the proteasome's engagement state.

This study designs and tests PROTACs targeting β-tubulin, showing two compounds effectively degrade tubulin in cells.

The paper describes a cGMP-compliant method for producing high-purity, RNAse-free plasmid DNA vaccine using 3L-scale fermentation and chromatography.

The paper demonstrates that adding an N-terminal biphenyl motif from LL-37 to short cathelicidin peptides significantly enhances their antibacterial activity against gram-negative bacteria.

This study presents the crystal structure of FKBP1A at 1.05 Å resolution and performs docking studies to explore potential drug repurposing opportunities.

The paper identifies a novel 6mA-binding protein from Vibrio cholerae that recognizes the G6mAG motif, differing from DpnI's G6mATC specificity.

This paper demonstrates that illumination, specifically blue light, enhances astaxanthin production in Chlamydomonas reinhardtii through phototropin-modulated biosynthetic gene clusters without genetic modification.

This paper introduces a method combining quantum cascade laser infrared imaging with mass spectrometry to improve molecular identification in spatial omics, achieving high-resolution lipidomics profiling.

The paper develops a mass spectrometry-based assay to screen E2/E3 ligase pairs for their ability to form ubiquitin chains and analyze chain types.

The paper shows that the H/ACA snoRNP snR30 forms a satellite particle to guide 18S rRNA subdomain folding before integrating into the 90S pre-ribosome, enhancing ribosome assembly accuracy.