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Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus

This study shows that mechanical flexibility improves DNA origami nanocarriers' transport through mucus by overcoming steric confinement, complementing surface passivation strategies.

Chemical Boosting of Foldase Condensates Accelerates Oxidative Protein Folding

This study develops a chemical method to enhance oxidative protein folding within PDIA6 condensates, showing up to 12-fold acceleration in vitro and improved insulin secretion in cells.

Comparing Vibrotactile Stimulation to Combined Visual and Auditory Stimulation for 40 Hz Gamma Entrainment

This study compares vibrotactile stimulation to combined visual and auditory stimulation for 40 Hz gamma entrainment, finding that vibrotactile stimulation evokes 40 Hz EEG responses and is preferred by participants.

Regio-selective sulfation of heparin mimicking polymers defines in vivo activity

This study develops and evaluates regioselectively sulfated polyamidosaccharides (disulPASs) as synthetic anticoagulants with activity similar to heparin.

Estimating Muscle Parameters via Hierarchical Bayesian Inference

This paper introduces a hierarchical Bayesian framework to estimate subject-specific muscle parameters using EMG and torque data, achieving high accuracy and robustness in musculoskeletal modeling.

Fibroblast alignment is governed by stiffness interfaces in hydrogels.

This study shows fibroblasts align differently at soft/soft vs. soft/stiff hydrogel interfaces, with increased myofibroblast differentiation at stiff interfaces due to mechanical cues alone.

Combination of 3D and 2D small and wide angle X-ray scattering imaging reveals diminished bone quality in the superior human femoral neck cortex

This study uses 2D and 3D X-ray scattering imaging to analyze bone nanostructure in the femoral neck, finding material property differences that may increase fracture risk in the superior region.

Photopatterned spatiotemporal organisation and in situ differentiation of 3D human cortical networks

This paper introduces a 3D human cortical network model using photopatterning to enable spatially controlled differentiation and maturation of neurons and glia, revealing developmental transitions and synaptic integration.

A realistic in-silico brain phantom for quantifying susceptibility anisotropy-induced error in susceptibility separation

The paper creates an in-silico brain phantom to evaluate how susceptibility anisotropy affects susceptibility separation algorithms, finding increased error in negative susceptibility estimates with anisotropy.

Vibration's frequency and intensity for optimal setup for enhancement bone response in small rodents: A systematic review and Bayesian network meta-analysis

This study identifies optimal vibration parameters for enhancing trabecular bone volume in small rodents through systematic review and Bayesian network meta-analysis.

Cost-Effective Purification of Endotoxin-Free LIF, IL-2, and IL-33

The paper describes a cost-effective E. coli-based method for producing endotoxin-free cytokines, demonstrating bioactivity comparable to commercial products at 5%-10% of the cost.

In Silico Optimisation of Regenerative Cell Therapy in the Infarcted Human Ventricles to Mitigate Arrhythmic Burden

This study uses multiscale modeling to identify anti-arrhythmic strategies for cell therapy in infarcted human ventricles, showing that blocking specific currents and upregulating others reduces arrhythmias while maintaining calcium function.

Device-embedded accelerometry complements neural signals for tracking parkinsonian motor states

This study shows that device-embedded accelerometry better tracks Parkinsonian motor states than neural signals during deep brain stimulation.

Expanding Microgel Parameters to Model the Tumor Microenvironment and Examine Temozolomide Resistance in Glioblastoma

This study uses cell-laden microgels to model GBM tumor microenvironment heterogeneity and screen TMZ resistance in patient-derived xenografts.

Consistency Analyses of Open-source Software for Motor Unit Decomposition Using High-density Electromyography Signal

This study evaluates the consistency of 7 open-source motor unit decomposition tools using HD-sEMG data, finding significant variability in results and requiring manual editing for reliable analysis.

When Color Adds Nothing: A Causal Audit of Channel Triplication in Alzheimer's MRI Classification

This paper tests if copying single-channel MRI data into three RGB channels affects classification models, finding most models are unaffected but some show significant changes.

Sonification of Elephant Infrasound

This paper develops a signal-processing pipeline to make elephant infrasound audible using psychoacoustic effects, enabling real-time perception and field deployment.

Pulmonary mRNA-LNP Vaccines for Rapid and Durable Protection Against Bacterial Infection

This paper develops a pulmonary mRNA-LNP vaccine that provides rapid and durable protection against bacterial lung infections by integrating innate and adaptive immune responses.

Behavioral and Functional Profiling of Acomys cahirinus Fibroblasts Reveals Enhanced Matrix Remodeling Capacity

This study profiles Acomys cahirinus fibroblasts to show that Col3A1 expression and senescence-associated cell states influence matrix remodeling, contributing to scarless regeneration.

CD117 epitope-shielded hematopoietic stem cell transplantation with toxin-free conditioning and in vivo selection ameliorates β-thalassemia model

This paper demonstrates a method using CD117-blocking antibody and epitope-engineered HSPCs to treat β-thalassemia without myeloablative conditioning.