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This paper demonstrates fast scanning SAXS on biological cells in aqueous environments to reveal intracellular anisotropy and orientation and assess radiation damage.

This study presents a method to generate asymmetric phosphoinositide lipid bilayers by spontaneous insertion of PI(4,5)P2, demonstrating its mobility and functional recruitment of actin-related proteins.

The paper evaluates FRET-based vinculin tension sensors to determine optimal design parameters for measuring molecular forces in cells.

This study measures the stall force of KIF1A motor protein using a DNA origami nanospring, revealing challenges in measuring KAND mutants.

This study investigates how different crowding agents affect protein phase separation using NMR, revealing residue-level environmental influences and highlighting the importance of crowder identity.

This study shows that the C-terminal domain of coronavirus E protein can modulate liposome shape by forming amyloid fibers, suggesting a mechanism for membrane interaction in host cells.

This study identifies REP elements as dual regulators of 3'UTR function in E. coli, controlling transcription termination and mRNA stability in a context-dependent manner.

This paper introduces BAFS, a method to measure receptor-antigen binding strength in immune synapses with high precision and reduced non-specific binding.

The paper determines the in situ structure of prefusion hemagglutinin on influenza virions and shows how HA trimers form cooperative assemblies that coordinate membrane fusion.

MORPHIS quantifies single-cell morphological responses to treatments and aging, distinguishing compound-specific signatures and aging-related changes in Caco-2, HeLa, and C. elegans cells.

This study measures the molecular effects of caldesmon on smooth muscle myosin force generation and relaxation using a laser-trap assay, showing CaD inhibits force and accelerates relaxation.

This study shows that both ATP and Mg2+ are required for high-affinity indolmycin binding to human mitochondrial TrpRS, revealing structural and thermodynamic similarities to bacterial TrpRS.

This paper introduces BISPIN, a framework to quantify weak stochastic magnetic fluctuations in living cells, distinguishing live cells from fixed ones and mapping subcellular magnetic activity.

This study characterizes the structure and function of MscM, revealing that its cytoplasmic domain mediates channel gating through conformational changes, differing from other MscS-like channels.

This study uses molecular dynamics simulations to predict antibody internalization by mapping energy landscapes between antibodies and JAM-A receptors, identifying key interactions that drive endocytosis.

This study uses molecular dynamics simulations to show that neck-region interactions with microtubules direct counterclockwise stepping in kinesin-1.

This study shows ATP forms protein-free condensates in crowded environments, which are responsive to stimuli and protect RNA from cleavage.

The paper uses live-cell tracking to show that hyperosmotic stress causes HOPS condensates to exhibit sub-diffusion due to ER tethering and super-diffusion via microtubule transport.

This paper introduces a method for nanoscale drift stabilization in thick non-transparent tissues using back-illumination phase imaging and cross-correlation analysis, enabling high-quality imaging of extracellular structures.

This study identifies the NS3 protease domain of Yellow Fever Virus as a high-affinity G4 binder, revealing its interaction mechanism and potential as an antiviral target.