Discover, rate, and discuss biology preprints.

This study determines the structure of AcMNPV nucleocapsid using CryoEM, revealing DNA portal organization and packaging apparatus features.

The paper compares monomer loss and severing as disassembly mechanisms in filament and bundle assembly, showing severing accelerates assembly and enables precise size control.

This study investigates protein-RNA condensation kinetics using a viral model, revealing the sequence of events leading to nanocluster formation and coacervate structures.

The paper introduces HMFF, a method integrating experimental data into membrane simulations, and applies it to various biological systems to enable multi-scale modeling.

The paper uses cryo-EM to visualize intermediate states of dynein activation pathway by analyzing structures of dynein and dynein-Lis1 bound to ATP.

This study shows that intrinsically disordered regions in Msn2 enhance DNA binding and promoter selectivity through non-specific association and one-dimensional diffusion.

FLIMPA is an open-source software for FLIM phasor analysis that integrates data from multiple trials and provides tools for quantifying microtubule depolymerisation.

This study uses molecular dynamics simulations to show that Stx1A TMD palmitoylation stabilizes its conformation, facilitates SNARE complex formation, and modulates fusion pore dynamics during neurotransmitter release.

The paper develops RINFAIRE to analyze multiconformer models of PTPs, revealing shared and unique allosteric networks and validating their functional impact through mutations.

The paper develops a method to predict intermolecular interactions between intrinsically disordered regions and partner proteins using chemical physics principles.

This study examines how surfactants affect the adsorption and desorption of monoclonal antibodies at the air-water interface, showing that P188 inhibits adsorption but not desorption, while PS20 can desorb fresh layers but not aged ones.

This paper presents a parallel implementation of the NERDSS software using MPI, achieving near-linear scaling for particle-based reaction-diffusion simulations up to 96 processors.

The paper shows that synthetic RNA with hairpin binding sites and disordered coat proteins form programmable polyphasic RNP granules with tunable phase behavior.

The paper performs all-atom MD simulations of the HPV16 capsid to study its structure, dynamics, and potential for drug design and antibody engineering.

The paper derives equations to quantify thermodynamic parameters of SARS-CoV-2 infection, highlighting the dual role of viscosity and cholesterol in pathophysiology.

This study identifies two distinct motility modes in cell pairs using a biophysical model, showing differences between amoeboid and mesenchymal cell types.

The paper studies cell packing on a growing surface using squid skin chromatophores, finding hyperdisordered scaling and size distribution patterns.

This study investigates how J-domain proteins induce conformational changes in Hsp70 to activate ATP hydrolysis through free energy simulations and network analysis.

The paper shows a protein-DNA co-condensate forms a surface hydrogel that mechanically reinforces the nucleus and protects DNA from damage during mechanical stress.

The paper uses single-molecule analysis to show how variant PRC1 complexes interact with chromatin and perform ubiquitylation, revealing subtype-specific activity differences.