Discover, rate, and discuss biology preprints.

The paper uses whole-genome sequencing data from UK Biobank participants to identify rare non-coding variants and regions associated with circulating protein levels.

The paper investigates the evolutionary lineage and ancestry of Listeria monocytogenes strains with unique methylase genes, finding they belong to Lineage I and are not orthologous to other bacterial genera.

This paper introduces two 3C-derived methods, Tri-4C and Tri-HiC, for ultrafine mapping of chromatin interactions at 100 basepair resolution, revealing regulatory genome architecture and enhancer-promoter loops.

The paper develops a method to profile sphingolipids in C. elegans and identifies the functional roles of specific isozymes in sphingolipid biosynthesis.

The paper identifies a genetic region associated with systemic necrosis in Arabidopsis thaliana infected with turnip mosaic virus, showing a trade-off between resistance and fitness costs.

This study shows that a polygenic risk score for coronary artery disease is associated with more severe atherosclerosis features in autopsy samples of sudden death cases.

The paper shows H3K9me2 regulates silencing through incoherent feedforward loops involving H3K36me3 and H3K4me1.

The paper shows that DNA double-strand breaks near inverted repeats drive inverted duplications in Sae2 and Mre11-deficient cells through a mechanism involving DNA polymerase delta and Rad51.

The paper examines dispensable essential genes and their association with bypass suppressor mutations across species, revealing distinct phylogenetic properties and evolutionary implications.

This study identifies ADR-2's role in regulating fertility and oocyte fate in C. elegans through RNA editing and genetic interactions with SQD-1.

This paper introduces EFA, a model that factorizes polygenic epistasis to improve prediction and uncover biological pathways in complex traits.

This study shows that HP1 proteins are essential for maintaining heterochromatin but not for its establishment, as their function can be bypassed when specific histone modifiers are deleted.

The paper identifies tissue-specific regulatory variants influencing blood pressure heritability using GWAS and gene expression data.

The paper develops a mathematical model to explain how DNA methylation patterns are established and inherited in Arabidopsis thaliana genes, showing they undergo long-term epigenetic fluctuations.

The paper uses multitrait GWAS to identify genetic links between MRI brain volume phenotypes and psychiatric disorders, finding significant associations with ADHD and schizophrenia.

The paper analyzes single-cell RNA sequencing data to show SGLT2 inhibition restores metabolic dysfunction in diabetic kidney disease by altering glycolysis and fatty acid oxidation in proximal tubule cells.

This study shows that Pot1 in fission yeast is essential for telomere DNA replication by recruiting the Stn1-Ten1 complex and Pol-primase, preventing ssDNA accumulation and telomere loss.

The paper identifies two DnaJ chaperone proteins, CG5001 and P58IPK, that reduce HTT aggregation in HD models, suggesting their potential as therapeutic targets.

The paper investigates how reduced dosage of dynein arm preassembly factors affects cilia regeneration in Chlamydomonas reinhardtii, finding that double heterozygosity limits dynein arm assembly.