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This study identifies NK cell dysfunction in keloids, showing IFN-γ suppresses fibroblast proliferation while AREG counteracts this, and systemic IFN-β drives NK cell exhaustion.

The paper identifies novel regulators of NK cell development and antiviral function through in vivo screening in mice, with relevance to human health.

This study shows that epithelial MHC II antigen presentation encodes tissue state and injury signals, maintaining homeostasis and promoting tolerance, while shifting toward damage-associated antigens during inflammation.

The paper shows that time of day influences the olfactory bulb's response to inflammatory challenges through rhythmic immune gene expression and microglial activity in mice.

This study shows stress hormones induce neutrophil extracellular trap formation, linking inflammation to behavioral changes in mice and humans.

This paper compares four assays for measuring anti-EBOV glycoprotein antibodies, finding they are concordant and that newer assays offer lower variability and higher throughput.

This study maps the chromatin dynamics during human MAIT cell development using CUT&Tag and transcriptome data, revealing H3K27ac changes linked to gene expression and effector program acquisition.

The paper shows that transient immune architecture changes during infection protect low-affinity CD8 T-cell priming from Treg inhibition, ensuring broad T-cell responses.

The paper uses multimodal imaging and single-cell transcriptomics to identify LPCAT2-mediated membrane remodeling in granuloma macrophages during visceral leishmaniasis.

This study identifies MIF-CD74 signaling as a regulator of trabecular meshwork dysfunction in glaucoma, showing its role in suppressing Blimp-1 and promoting ECM remodeling and cytoskeletal changes.

This study shows that UVB-induced DNA damage activates DDR and innate immune pathways in sea urchin coelomocytes, revealing conserved mechanisms linking DDR with immunity in invertebrates.

This study shows that Pseudomonas aeruginosa mutants lacking the H3-T6SS exploit itaconate to persist in phagocytes, enhancing their ability to cause chronic lung infections.

This study designs hypoallergenic variants of Fel d 1 by disrupting IgE-binding sites, showing reduced IgE reactivity and suppressed basophil activation ex vivo.

This study maps immune cell dynamics during human sequential lymph node metastasis using multi-omics approaches and identifies immune alterations linked to patient survival.

This study investigates how IL-33 affects platelet proteome, function, and production, revealing its role in inflammation and thrombopoiesis.

This study identifies Trem2hi macrophages as mediators bridging inflammation resolution and fibrosis initiation after kidney injury, showing their role in promoting fibrosis through specific mechanisms.

This study examines how MAIT cells respond to S. aureus and how their sensitivity to the toxin HlgAB varies by tissue location and activation state.

This study identifies HLA allele-specific biases in TCR Vβ usage, showing germline-encoded preferences shape TCR-HLA compatibility and influence TCR-pHLA specificity.