Discover, rate, and discuss biology preprints.

This study investigates the impact of E. aedis infection on the bacterial microbiota of Ae. aegypti and finds no significant changes in microbiota composition or function.

Immune responses in healthy mammals are shaped by exposure to infected conspecifics.

This study identifies a hybrid inflammasome formed by NLRP1 and NLRP3 in human cells, associated with inflammation in inflammasomopathies and transplant patients.

This study develops a humanized SLE model to compare B cell-targeted therapies, finding UCAR-T provides better renal and autoantibody reduction than TCEs despite higher toxicity.

The paper shows that cysteine in CD8+ T cells is partitioned into glutathione and FeS-cluster synthesis, supporting effector functions and proliferation, respectively.

The paper infers memory B cell and plasmablast dynamics using statistical methods, finding slow clone degradation and high plasmablast differentiation rates.

This study identifies metabolic dysregulation of autophagy in HS, linking mTOR activation and cadaverine to inflammation, pain, and malodor.

This study designs a dual-epitope vaccine targeting HIV-1 Env's fusion peptide and V2 apex, showing it elicits neutralizing antibodies against both sites in rhesus macaques.

This study shows that murine cytomegalovirus infection exacerbates inflammation in Pkp2 mutant mice but not in Ttn mutant mice, highlighting the interaction between genetic predisposition and environmental factors in cardiomyopathy.

The paper shows that inhibiting IFI16 and AIM2 in myeloid cells from HIV-1 patients reduces Gal-9 and PVR, enhancing CD8+ T-cell responses against HIV-1.

This study investigates immune responses to SARS-CoV-2 and EBV in neuropsychiatric long COVID patients and finds reduced EBV neutralization linked to persistent fatigue.

This study compares the biodistribution of rigid and flexible liposomes in the spleen and identifies APC subsets involved in immune tolerance.

The study investigates SARS-CoV-2 exposure in roe deer populations in France using serological and PCR tests, finding possible cross-reaction with unidentified coronaviruses rather than SARS-CoV-2 emergence.

This study shows that excess IL-18 protects against CNS autoimmunity by activating CD8 T-cells to suppress CD4 T-cells involved in autoimmune encephalomyelitis.

The paper introduces a scalable TCR synthesis and screening method, TCRAFT, to map antigen reactivity in vitiligo and pancreatic ductal adenocarcinoma.

This study shows mast cells drive tuberculosis pathology by promoting inflammation and Mtb dissemination, with distinct transcriptional programs in active versus latent infection.

The paper shows that miR-195 can rescue B cell development in EBF1-deficient progenitor cells by enabling CD19 expression and recombination processes.

This study shows that latent cytomegalovirus infection reduces NK cell responses to Plasmodium falciparum and impairs parasite control by disrupting IL-12 production.

This study shows fructose metabolism in GM-CSF-differentiated macrophages promotes autoimmune inflammation through MG-AGE-RAGE signaling by enhancing glycolysis and Th17 differentiation.

The paper introduces a model-based approach to predict signal spread in spectral flow cytometry during panel design, demonstrating its reliability across multiple samples.