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This study identifies sex-specific metabolic differences in human neutrophil subsets, showing male low-density neutrophils have higher oxidative and glycolytic activity compared to female counterparts, independent of maturity.

This study shows neonatal BCG vaccination expands IL-17/IL-22-producing γδ T cells, mediates protection against TB, and induces a microbiome signature linked to gut-lung axis immunity.

The paper identifies reduced effector and cytotoxic T-cell gene expression in early type 1 diabetes across multiple T-cell subsets using single-cell transcriptomics and flow cytometry.

This study examines how a Treg-selective IL-2 mutein affects influenza-specific T cell responses, showing opposing effects based on administration timing.

This study uses spectral flow cytometry to analyze age-related changes in innate and innate-like T cells, identifying age-associated phenotypic shifts in immune cell subsets.

This study identifies Noxa's role in metabolic reprogramming to glutamine dependence in CD8+ T cells, independent of its canonical apoptotic function, and suggests its potential as an immunotherapeutic target.

This study identifies innate antiviral readiness as a key driver of TSCM cell expansion, showing its predictive value for viral clearance and vaccine design.

The paper investigates immune cell senescence in melanoma patients and finds that non-responders to immunotherapy have higher senescence in immune cells compared to responders.

This study shows chronic compression transforms macrophages into a pro-tumor state, resembling glioma-associated macrophages, independent of tumor cell factors.

This study evaluates the immune response and efficacy of co-administering a bovine tuberculosis vaccine (BCG) and a contraceptive vaccine (GonaCon) in badgers, finding no significant adverse effects and potential enhanced BCG protection with booster vaccination.

This study shows PD-1 blockade enhances HIV-1 vaccine-induced CD8+ T-cell responses in early ART-treated PWH, improving proliferation, IFN-gamma production, and activation.

The paper shows that early life regulatory T cells (ETregs) regulate PPAR-gamma signaling in hair follicles, which is essential for melanocyte stem cell-mediated skin pigmentation.

This study identifies RNY1 as a YRNA that partitions into extracellular vesicles and ribonucleoprotein particles during airway inflammation, influencing macrophage activation through distinct mechanisms.

The paper maps dynamic RNA-binding proteins in human effector T cells and identifies TUT1 and SF3A1 as regulators of differentiation and cytotoxicity.

This study identifies a novel Clec7a-KLR axis that regulates DC function and CD4 T cell responses, linking innate and adaptive immunity in host defense and inflammation.

This study shows dietary restriction enhances CD8+ T cell ketolysis, improving mitochondrial function and anti-tumor immunity by reducing exhaustion.

This study shows dietary indoles restore gut barrier function in SIV-infected macaques by reactivating the AhR-IL-22 pathway, reducing intestinal epithelial barrier disruption markers.

This study shows that galectin-9 in dendritic cells is necessary for organizing HLA-II at immune synapses, which enhances CD4+ T cell activation and anti-tumor immunity.

This paper evaluates a tuberculosis vaccine regimen in mouse models, finding it highly effective in preventing reactivation and acute infection by enhancing specific immune cell populations.

This paper introduces a modular immunogen platform that displays multiple hemagglutinin subtypes and elicits cross-reactive immune responses against influenza subtypes not included in the immunogen.