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This study uses single-cell RNA sequencing to identify CD4+ T cell phenotypes in psoriasis patients associated with response to IL-23 blockade.

This paper evaluates two bispecific CD20xCD40 antibodies, showing they modulate multiple immune cell types and achieve deep immunomodulation without safety issues.

The paper tracks tnfb expression in zebrafish using reporter lines and scRNAseq, showing distinct kinetics and cell-type-specific expression compared to tnfa and il1b.

This study compares neutralization susceptibility of clade C HIV viruses from breastmilk to those from sexual transmission, finding breastmilk viruses more resistant to certain broadly neutralizing antibodies.

This study characterizes the lipid composition of SARS-CoV-2 envelopes from cultured strains and patient isolates, showing inflammation-induced changes and identifying lipid targets for antiviral and antithrombotic strategies.

This study identifies circCPSF6 as an antiviral factor that regulates host innate immunity by sequestering miR-665 and modulating PCBP2-IPS-1 interactions.

This study evaluates the cross-species neutralization potential of monoclonal antibodies against PfCyRPA and PfRIPR against P. knowlesi, finding minimal inhibition despite partial epitope conservation.

This study identifies a mitochondrial-iron axis that drives lipid droplet formation in aging microglia and neurons through reactive oxygen species, revealing a microglia-neuron axis regulating iron metabolism.

This study shows that the time of day affects cancer immunotherapy efficacy through a circadian clock-dependent chemokine axis in mice.

This study identifies transcriptomic differences in SLE neutrophils, shows shared ex vivo adaptation with healthy cells, and demonstrates CAR T-cell therapy can reset neutrophil gene expression toward healthy patterns.

The paper examines how B-cell subsets in ocrelizumab-treated multiple sclerosis patients influence vaccine responses to SARS-CoV-2, identifying specific B-cell populations associated with immune response variability.

This study shows that NMUR-1 in C. elegans neurons controls energy homeostasis and innate immune specificity through ATP regulation in response to bacterial pathogens.

The study shows that prior Mtb infection protects against reinfection with a genetically distinct strain in macaques, suggesting broad vaccine efficacy across Mtb lineages.

This study identifies IRF4 as a master regulator of multinucleated giant cell formation through integrated single-cell and bulk RNA sequencing, CRISPR/Cas9 editing, and in vivo fate mapping.

The paper evaluates the effects of Zap70 and Itk inhibitors on T cell activation and identifies novel phosphotyrosine targets using proteomics.

This paper investigates the role of mast cell ST2 in Heligmosomoides polygyrus bakeri infection using transcriptomic and proteomic analysis, finding minimal impact on infection outcomes.

This study shows zebrafish type I interferons target different tissues, mirroring the mammalian division between type I and type III IFNs.

This study investigates the constraints on the breadth evolution of the CR9114 broadly neutralizing antibody by comparing binding affinity landscapes across different influenza HA subtypes.

This study shows that CD8 T cells infiltrate kidneys in lupus mice and correlate with disease progression, but do not dominate over CD4 T cells.