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The paper builds a machine learning model to predict KIR3DL1 binding to HLA class I allotypes, showing that binding is influenced by multiple non-additive regions beyond the classical Bw4 motif.

This study shows that SHIP1 regulates TREM2 signaling and macrophage functions in hiPSC-derived macrophages, affecting inflammation and phagocytosis.

The paper identifies early T and NK-cell dysfunction in dengue patients that predicts severe disease, with obesity exacerbating these signatures.

This study identifies CD4+ T cell epitopes in chronic chikungunya virus disease, revealing conserved epitopes across alphaviruses and providing tools for T cell response analysis.

Deleting early riboflavin genes (ribA2 in both species, ribG in M. smegmatis) sharply reduced MAIT cell activation, while ribH deletion raised recognition of M. tuberculosis only.

This study uses CRISPR, Tocky, and machine learning to analyze Foxp3 transcription dynamics in mice, revealing CNS2-dependent regulation and age-related expression patterns.

This study identifies LAG3 as a marker of dysfunctional NK cells that are activated but hyporesponsive in various inflammatory conditions.

The paper investigates the effects of red and black iron oxide pigments on macrophages, finding that red iron oxide causes mitochondrial dysfunction, oxidative stress, and pro-inflammatory cytokine secretion.

This study identifies and characterizes IRF3 and IRF9 genes in avian species, confirming their roles in IFN signaling and revealing evolutionary patterns.

The paper examines how mutations and a deletion in the KP.3.1.1 SARS-CoV-2 spike protein affect ACE2 binding and antibody escape, revealing structural and functional insights into its evolution.

The paper investigates how aging and viral mutations affect pan-coronavirus immunity, finding reduced T cell responses in older individuals and mutation-driven impact on humoral immunity.

This study shows that Spike-specific IgG4 generated after BNT162b2 vaccination can inhibit effector functions when competing with other IgG subclasses, despite overall increased neutralization and effector activity.

This study compares how synovial fluid from systemic juvenile idiopathic arthritis (sJIA) and JIA patients influences T helper cell polarization, showing sJIA SF promotes a specific Tph phenotype linked to IL-1β, IL-18, and GM-CSF.

The paper identifies Tmem127 as a regulator of T cell homeostasis by controlling IL-7 receptor surface expression and common gamma chain interactions.

This study examines immune remodeling after aHSCT in RRMS patients, finding lineage-specific changes in T and B cells rather than full immune restoration.

This study examines inflammation in fibrotic areas of kidney biopsies from lupus nephritis patients and finds that the degree of inflammation correlates with future kidney function decline.

This study constructs a recombinant Bacillus subtilis spore displaying PRRSV proteins and evaluates its immunogenicity in mice, showing enhanced mucosal and systemic immune responses.

This study investigates how antibodies affect B cell receptor access to viral epitopes, finding that proximity, affinity, and valency influence epitope masking.

This study uses ex vivo human lymph node slices to investigate immune responses to a vaccine adjuvant, identifying IL-1β secretion as TLR4-dependent and highlighting roles for innate lymphoid and stromal cells.

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 that target conserved regions on the spike RBD, showing resistance to antigenic drift and suggesting potential vaccine targets.