Discover, rate, and discuss biology preprints.

The paper validates CD101 as a reliable marker for mature neutrophils using a reporter mouse model and shows its stability under pathological conditions.

This study evaluates adaptive focused acoustics (AFA) technology for macrophage lysis and proteomics, showing improved proteome coverage, reproducibility, and detection of low-abundance immune proteins.

This study shows miR-29a reprograms exhausted CD8 T cells into a stem-like state, enhancing their effector function and response to checkpoint inhibitors.

The paper introduces dia-PASEF, a mass spectrometry workflow for rapid secretome profiling, revealing novel inflammatory responses and dynamic secretion patterns in macrophages.

This study shows that long-term low-dose rapamycin reduces IL-17-producing gamma delta T cells and neuroinflammation in aging.

This study identifies distinct transcriptional features in fibroblasts and myeloid cells of ICI-LP compared to LP, highlighting differences in IGF1, JAK-STAT, and interferon pathways.

FOXP3-engineered regulatory T cells enhance intestinal barrier function in Crohn's disease enteroids via the PDGF-AA-PDGFR axis, independent of their immunosuppressive role.

This study shows that topical lubrication can regenerate the damaged corneal stroma in a mouse model by converting inflammatory keratocytes into reparative cells.

This paper shows that vagus nerve stimulation reduces colonic inflammation in mice, but only if the colon has a history of prior inflammation.

This study compares neutralizing antibody titers from egg-derived and recombinant protein influenza vaccines against diverse H1N1 strains, finding that egg-derived vaccines induce less boost against a new clade with specific antigenic mutations.

The paper identifies SPIC-dependent VCAM1+ macrophages as drivers of granuloma formation and bacterial persistence during Salmonella infection.

This study shows that intracellular pathogens like Coxiella burnetii synergize with IFNγ signaling to enhance pro-inflammatory cytokine expression, with STAT3 activation playing a key role.

The paper develops a multiplex phosphoflow assay to profile age- and immune cell-specific signaling activation in 18 subpopulations, revealing distinct patterns in healthy individuals aged 1-69 years.

The paper identifies distinct gene signatures in effector T cells from poorly perfused tumor regions, showing enhanced IFN response and reduced PD-1 expression.

This study investigates the immunomodulatory effects of SHP2-based vertical RAS pathway inhibition in pancreatic cancer, revealing both immune-activating and suppressive changes that evolve with treatment.

This study shows ACLY links metabolism to chromatin accessibility in B cells, essential for activation and humoral immunity.

The paper shows that reduced m6A in alveolar macrophages after influenza enhances trained immunity, improving antibacterial function and protecting against secondary infections.

This study finds low neutralizing antibody prevalence to GRAd32 in southern African populations, suggesting its potential as an HIV vaccine vector despite prior Ad26 vaccination.

This study identifies IFNγ-induced HLA class I-restricted neuronal autoantigens and their recognition by CD8+ T cells using human iPSC-derived neurons and immunopeptidomics.

The paper shows ibrutinib increases CD19 expression in B-cell lymphoma models, improving the effectiveness of CD19-CAR T cells.