Discover, rate, and discuss biology preprints.

This paper develops a microbial-abiotic sulfur relay to remediate bauxite residue by generating acidity and dealkalizing it, enabling plant colonization.

This paper reports cryo-EM structures of EMO and EMO-ETF complex from Syntrophus aciditrophicus, revealing a twin-heme-mediated reverse redox-loop mechanism for methanogenesis from fatty acids.

The paper analyzes microbial metabolic potential for CO2 and CH4 emissions in prawn ponds using genome-resolved metagenomics, finding that seasonal dynamics influence functional gene abundances more than management practices.

This study identifies promoter-dependent nuclear export as a mechanism for influenza A virus to select its genome for packaging into virions.

This study uses cryo-EM and computational methods to model the structure of HPV16 L2 protein within the capsid, revealing its conformational flexibility and positioning for virus entry.

This study shows that small cell variants of Coxiella burnetii replicate more efficiently than large cell variants in macrophages and fibroblasts, influencing early infection progression.

This study shows bacterial endosymbionts in fungal pathogens enhance virulence by altering the rhizosphere microbiome and reducing disease-suppressive bacteria.

This study uses high-resolution spatial transcriptomics to map viral tropism and immune responses in neonatal mouse brains infected with reovirus, revealing spatial patterns of infection and immune module organization.

This study shows H5N1 influenza virus can be transmitted vertically through placental and mammary routes in pregnant mice, causing developmental impairments in offspring.

This study shows that nicotinamide treatment reduces gut dysbiosis in middle-aged rodents with a history of neonatal maternal separation.

GUIbiont is a no-code tool for analyzing microbial growth data, enabling quality control, curve fitting, and metadata-linked analysis, validated on E. coli deletion strains and defined-media curves.

This study shows how Vibrio cholerae pellicles form through planktonic cell recruitment mediated by extracellular matrix factors and quorum-sensing.

This study shows that incomplete killing by antimicrobial metals like copper and silver in Escherichia coli leads to transient antibiotic tolerance through delayed recovery, not genetic changes.

This study determines the structure of a large S-layer protein from Pyrobaculum arsenaticum using cryo-EM and AlphaFold, revealing its unique multidomain architecture and evolutionary conservation.

This paper shows a bacterial consortium degrades PET plastic through ancestral hydrocarbon metabolism and division of labor, not specialized PET pathways.

ResLit couples BioMistral-7B screening with two-pass Qwen3-30B extraction to build an antimicrobial-resistance database of 3,120 genes and 13,593 mutations, evidence-tiered against CARD, ResFinder, and NCBI RGC.

This study identifies dalberoside, a glycolipid that inhibits bacterial surface attachment and biofilm formation by remodeling the outer membrane interface without killing bacteria.

This study uses codon deoptimization to create attenuated Rift Valley Fever Virus (RVFV) vaccine candidates, showing varying degrees of attenuation with the dual-segment deoptimized virus as a promising live-attenuated vaccine.

The paper experimentally demonstrates that algal pigmentation, specifically astaxanthin, significantly reduces snow reflectance, independent of cell abundance and developmental stage.

The paper redefines IS110 as a dynamic platform capable of expanding into large elements that disseminate antimicrobial resistance.