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This study shows that titin cleavage in mice causes concentric cardiac remodeling, diastolic dysfunction, and fibrosis by disrupting mechanical connectivity.

This study shows semaglutide improves mitochondrial energy efficiency in skeletal muscle by enhancing ATP production per oxygen consumed during weight loss.

The paper shows partially differentiated CFTR-mutant enteroids secrete fluid in response to forskolin and linaclotide, with reduced efficacy compared to healthy enteroids.

This study investigates how Ang-II affects NCC through Kir4.1/Kir5.1 in the DCT, finding that short-term effects depend on Kir4.1/Kir5.1, while long-term effects are independent.

This paper demonstrates that endothelial cells can delaminate from a vessel wall to form transluminal bridges, enabling intussusceptive angiogenesis, using a microvessel-on-a-chip model.

This study shows that exogenous thyroxine improves antioxidant defenses and reduces oxidative stress in insulin-resistant OLETF rats.

This study shows that prenatal cannabinoid exposure impairs respiratory and autonomic control in juvenile rats, with sex-specific effects on reflex responses to hypoxia and hypercapnia.

This study shows that fetal serum from obese pregnant women induces pathological cardiomyocyte hypertrophy in neonatal rats through circulating factors.

This study identifies unique cardiac metabolic adaptations in Egyptian fruit bats using metabolomics and computational modeling, revealing reliance on lipid oxidation and oxidative phosphorylation.

After true ileal digestibility adjustment, about half of 193 long-term New Zealand vegans fell short of lysine and leucine requirements, though most met the protein Estimated Average Requirement.

This study isolates and analyzes brain-derived extracellular vesicles from umbilical cord blood to detect non-infectious neuroinflammation and neonatal iron deficiency in infants.

This paper develops a knock-in rabbit model of LQT2 with KCNH2 deletion, showing prolonged QT intervals, seizures, and sudden death similar to human LQT2.

This study shows that consuming glucosinolate-rich red kale sprouts reduces blood lactate during submaximal cycling and increases resting blood glucose.

This study examines how hair cortisol and oxytocin levels relate to training load and mental health in female soccer players, finding that oxytocin moderates the relationship between training load and cortisol.

This study shows Prex1 regulates glucose homeostasis by reducing glucose uptake and mitochondrial metabolism in the liver, independent of its catalytic activity, through Gpr21 inhibition.

The paper shows that dietary amino acid manipulation in marmosets affects serum metabolites and FGF21 levels, suggesting evolutionary conservation of the mechanism.

This study measures tongue base shape changes during respiration, chewing, and swallowing in minipigs using SONO and EMG, revealing distinct kinematic patterns for each function.

This study investigates MSCs from neonates of obese mothers, finding disrupted stemness and redox homeostasis linked to increased adiposity.

This study challenges the assumption that reduced Gompertz parameter {beta} indicates decelerated aging by showing it results from expanded decrepitude in long-lived C. elegans.