Discover, rate, and discuss biology preprints.

This study develops glomerulus-targeted nanotherapy using collagen IV-α3 binding peptides to improve renal function and reduce inflammation in lupus nephritis.

This study identifies liriodendrin as a compound that targets PFKFB3 to reduce inflammation and vascular remodeling in pulmonary hypertension.

This study investigates the role of ERBB4 in fibroblasts and myeloid cells during neonatal cardiac regeneration after myocardial infarction, finding that fibroblast-specific deletion modestly impairs scar resolution while myeloid-specific deletion increases initial injury response but not long-term regeneration.

This study examines how adult king penguins respond to chronic corticosterone exposure, finding they show resistance and resilience to its negative effects on physiology.

This study examines the effects of a maternal ketogenic diet on metabolic health in mice, finding altered maternal glucose homeostasis, reduced fetal growth, and sex-specific metabolic changes in offspring.

This study shows that combining tyrosol with creatine monohydrate improves muscle strength and endurance in trained mice, with greater recovery capacity after exhaustive exercise.

This study identifies transcriptional impairments in mitochondrial and protein homeostasis pathways in islets during type 1 diabetes pathogenesis, independent of T-cell infiltration.

This study identifies ACSF3 as a diurnal regulator of lysine-malonylation and hepatic metabolism, showing its rhythmic expression and role in glycogen storage, lipogenesis, and triglyceride synthesis.

This study shows that reducing MLKL in mice prevents diet-induced obesity and improves insulin signaling in fat cells.

This study identifies shared and sex-specific molecular responses to endurance training in skeletal muscle using multi-omics data from rats.

This study identifies miR-100-5p as a regulator of postprandial triglyceride response by targeting PCSK9, suggesting its potential as a biomarker for cardiovascular risk.

This study identifies the HIF-1 pathway as mediating the cardioprotective effects of GHRH-agonists in a murine model of cardiometabolic HFpEF.

This study identifies DI-1859, a selective Cul3 neddylation inhibitor, that reduces hyperglycemia by enhancing insulin sensitivity and secretion in mice.

This study identifies SLC25A34 as a fasting-inducible mitochondrial carrier that mediates PEP import, linking amino acid catabolism to muscle preservation during fasting.

This study identifies Notch signaling in hypothalamic oligodendrocytes as a regulator of systemic energy balance, showing that inhibiting Notch ligands leads to weight loss and metabolic changes.

This study shows that secretin receptor knockout mice have impaired renal base excretion and increased base retention during prolonged base-loading.

The paper identifies MARPs as key modulators of titin-based mechanotransduction and shows mTORC1 regulates longitudinal muscle hypertrophy in response to stretch.

This paper quantitatively analyzes gas embolic disease in sea turtles using ultrasound, finding organ-specific gas burden differences and temporal evolution between on-board and shore-based groups.

A 32-week plyometric training program improved jumping performance and reduced force-velocity imbalance in collegiate volleyball players compared to a low-intensity control group.