A. Ghosh

This study identifies miR-181a-5p as a regulator of EMT and chemoresistance in advanced retinoblastoma by reversing drug resistance through targeting ZEB1 and SNAI2.

This study shows that Nlj16 recruits LegH to the membrane of infected nodule cells, essential for oxygen sequestration during symbiotic nitrogen fixation.

The paper identifies two point mutations in PCDH1 that disrupt ANDV recognition and protect against lethal infection in Syrian hamsters.

The paper shows restoring PITPNA in T2D human islets reverses beta-cell dysfunction by improving insulin granule maturation and glucose-stimulated insulin secretion.

This study investigates how c-di-AMP synthesis and degradation are transcriptionally regulated in M. smegmatis, revealing a sub-operon promoter arrangement and autoregulation mechanisms.

This study shows that PIP4K regulates cell size and autophagy in Drosophila by controlling PI3P levels, with implications for neurodegeneration and tumour growth.

The paper characterizes the extracellular RNA pool in maize apoplast under normal conditions and during Ustilago maydis infection, finding increased abundance and enrichment in ribosome biogenesis transcripts.

This study uses AFM-IR to show structural heterogeneity in amyloid aggregates, revealing that fibrils can have structurally different domains and that early-stage aggregates exhibit varied conformations.

This study investigates how c-di-AMP signaling affects antibiotic tolerance in Mycobacterium smegmatis by analyzing resistant mutants and persisters.

This study develops autonomous microinjectors for GI delivery of insulin, showing they can deliver insulin systemically at levels comparable to intravenous administration.

This study shows that 14-3-3ζ regulates insulin secretion in pancreatic β-cells by enhancing mitochondrial function and ATP synthesis, with implications for diabetes.

This study investigates the structural domains of FtsY in Sulfolobus acidocaldarius that facilitate SRP54 binding and membrane association during protein translocation.

This study sequenced Mtb genomes from eastern India to analyze genotypic and phenotypic diversity, revealing high prevalence of MDR lineage-2 strains in NE and lineage-1/3 in Odisha, with local transmission clusters and enrichment of short INDELs in MDR samples.

This study identifies CMTM6 as a regulator of ribosome biogenesis in cisplatin-resistant OSCC, showing that targeting this pathway can restore chemosensitivity.

This study investigates the role of c-di-AMP in Mycobacterium smegmatis by analyzing mutants with altered c-di-AMP levels, revealing its impact on phenotypes, stress adaptation, biofilm formation, and antibiotic tolerance.

This study tests reward quantity discrimination in wild zebrafish using an operant conditioning task and finds some fish can discriminate between stimuli associated with different rewards.

This study identifies an evolutionarily conserved 'E-L-L' motif in the SARS-CoV-2 spike protein as a target for small molecule fusion inhibitors, showing posaconazole effectively blocks viral entry across variants.

This study evaluates the combined solar photo-Fenton and bacterial degradation of chlorpyrifos in wastewater and assesses its toxicity to zebrafish.

This study shows that combustible and electronic cigarette exposures increase ACE2 activity and SARS-CoV-2 Spike binding, potentially increasing infection risk.

This study identifies age-related behavioral changes in smartphone touchscreen interactions by analyzing temporal clusters of inter-touch intervals across a wide age range.

This paper introduces a DNA-based FRET sensor for non-invasive optical monitoring of intracellular mechanical forces in vitro and in living cells.

The paper isolates and characterizes five SARS-CoV-2 strains from India, showing variations in cytotoxicity and cell line permissiveness, and finds both Covaxin and Covishield vaccines neutralize all isolates effectively.

This study develops a reliable alveolar type 2 organoid platform to model diverse genetic subtypes of lung adenocarcinoma in vitro and in vivo.

The paper shows that SOCS1 deficiency leads to increased SOCS3 expression, which activates the p53-p21-NRF2 axis, reducing oxidative stress and HCC progression.

The paper identifies high enhancer activity in HPV-negative atypical HNSCC as linked to BET inhibitor resistance and upregulated signaling pathways.

This study identifies dynamic phenotypic states in oral cancer cells and their association with poor prognosis through transcriptomic heterogeneity and drug tolerance.

This study identifies distinct molecular trajectories in fibroblast reprogramming to myogenic progenitor cells versus myogenic transdifferentiation, highlighting Notch pathway activation as critical for iMPC formation.

This study uses AFM-IR to reveal structurally distinct polymorphs in tau aggregates, showing different secondary structures and antiparallel beta sheets in mature fibrils.

This study maps the bromodomain interactome using chemoproteomic methods, revealing new interactions and structural insights into BET protein function.

This study shows that Tmod3 regulates actin cytoskeleton assembly via Tpms during erythroid differentiation, essential for cell morphology and survival.