A. Sanchez

Exploring the interaction network of a synthetic gut bacterial community

This study investigates the interaction network of a synthetic gut bacterial community, revealing exploitative and interference competition shaping community dynamics.

Effect of Highly Loaded Nanohydroxyapatite Composite Scaffolds Prepared via Melt Extrusion Additive Manufacturing on the Osteogenic Differentiation of Human Mesenchymal Stromal Cells

This study evaluates the osteogenic potential of highly loaded nanohydroxyapatite scaffolds fabricated via melt extrusion additive manufacturing, showing enhanced mechanical properties and potential for in vitro and in vivo osteoinduction.

Africanized honeybees in Colombia exhibit high prevalence but low level of infestation of Varroa mites and low prevalence of pathogenic viruses

The study examines Varroa mite prevalence and virus infection in Africanized honeybees in Colombia, finding high mite prevalence but low infestation and virus prevalence compared to other regions.

Obesity-Activated Lung Stomal Cells Promote Myeloid-Lineage Cell Accumulation and Breast Cancer Metastasis

This study shows obesity modifies lung stromal cells to create pre-metastatic niches that enhance myeloid cell recruitment and breast cancer metastasis.

Development and pre-clinical characterization of two therapeutic equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19

This paper develops and pre-clinically evaluates two equine-derived anti-SARS-CoV-2 polyclonal formulations for potential COVID-19 treatment, showing high neutralizing capacity against SARS-CoV-2 infection.

Nutrient dominance governs the assembly of microbial communities in mixed nutrient environments

The paper investigates how nutrient interactions influence microbial community composition and finds that nutrient dominance patterns can predict community assembly in mixed nutrient environments.

Top-down engineering of complex communities by directed evolution

This study develops a modeling framework to explore directed evolution strategies for engineering complex microbial communities, identifying effective methods to enhance their stability and functionality.

CellCountCV - a web-application for accurate cell counting and automated batch processing of microscopy images using fully-convolutional neural networks

CellCountCV is a web-application using fully-convolutional neural networks for accurate cell counting and batch processing of microscopy images, achieving <4% error compared to expert estimates.

3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration

This study develops 3D scaffolds with antibiotic-loaded inorganic fillers for bone infection prevention and tissue regeneration, showing sustained antibiotic release and compatibility with cell differentiation.

Artificially selecting microbial communities using propagule strategies

The paper uses artificial selection experiments to compare propagule strategies in microbial communities, finding that selected communities achieve higher function than controls in two different experimental setups.

IRF8 Governs Tumor-Associated Macrophage Control of T Cell Exhaustion

This study identifies IRF8 as a key factor in tumor-associated macrophages (TAMs) that induce T cell exhaustion by presenting cancer antigens, and shows its association with poor patient survival in renal cell carcinoma.

Metabolic rules of microbial community assembly

This study shows microbial community assembly is predictable from metabolic principles, with taxonomic variability explained by competitive exclusion within functional groups.

Dissimilarity-Overlap Analysis of Replicate Enrichment Communities

The paper uses DOA to analyze in vitro microbial communities, finding a negative correlation between dissimilarity and overlap in replicate habitats, suggesting potential for universal dynamics but not absolute universality.

Regulation of the MLH1-MLH3 endonuclease in meiosis

This paper identifies the molecular mechanism by which the MLH1-MLH3 nuclease is activated in meiosis, showing its interaction with MutSγ, EXO1, RFC, and PCNA to process recombination intermediates.

Transcription-replication conflicts as a source of common fragile site instability caused by BMI1-RNF2 deficiency

This study shows that BMI1 and RNF2 suppress transcription-replication conflicts and CFS instability by regulating RNA Pol II elongation and fork protection.

Available energy fluxes drive a transition in the diversity, stability, and functional structure of microbial communities

This study shows that available energy fluxes drive a transition in microbial community diversity, stability, and function, shifting from resource-limited to preference-driven regimes.

Microbiota profiling with long amplicons using Nanopore sequencing: full-length 16S rRNA gene and whole rrn operon

This study evaluates long-amplicon PCR-based approaches using Nanopore sequencing for microbiota profiling at genus and species levels, finding that the rrn operon provides higher resolution than full-length 16S rRNA.

Sexual maturation and embryonic development in octopus: use of energy and antioxidant defense mechanisms using Octopus mimus as a model.

This study examines changes in biochemical composition during gonadal maturation in Octopus mimus and its effects on embryo and hatchling characteristics, including energy use and antioxidant defenses.

High-order interactions dominate the functional landscape of microbial consortia

The paper shows that high-order interactions dominate the amylolytic function of microbial consortia, making community function unpredictable as size increases.

On the deformability of an empirical fitness landscape by microbial evolution

This study examines how metabolic mutations deform the fitness landscape of E. coli, showing short-range limited effects but long-term legacy impacts on evolutionary trajectories.

Emergent Simplicity in Microbial Community Assembly

The paper shows that microbial communities re-assemble into predictable, stable communities through non-specific metabolic cross-feeding, even when grown in minimal environments.

Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in polynucleotide kinase/phosphatase mutant of fission yeast

This paper shows that in fission yeast lacking PNKP, lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks through alternative pathways.