C. Li

The paper determines the structure of mTORC2 and shows how substrate-specific interactions and conformational changes regulate its activity.

This study identifies OsDML4 as a demethylase gene whose knockout under high temperature causes floury endosperm by altering DNA methylation and gene expression in rice.

The paper identifies a new protein sensor class (CheWS) in Treponema denticola that links spirochete morphology, persistence, and chemotaxis through SAM sensing.

This paper identifies two conserved regions on the Omicron RBD recognized by broadly neutralizing antibodies and develops an inhalable bispecific antibody with broad neutralization and therapeutic efficacy in mice.

This paper develops self-powered artificial cell colonies that mimic muscle behavior through actin polymerization and depolymerization, showing reversible deformation and collective contraction.

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

This paper introduces a new collective variable based on graph theory to quantify water wire connectivity and proton translocation in confined spaces, revealing that water connectivity, not just presence, is critical for proton transport.

This study shows dihydroartemisinin (DHA) enhances anti-PD-1 therapy in hepatocellular carcinoma by inhibiting YAP1 and disrupting immune evasion through PD-L1, JAK1/STAT1, and JAK3 pathways.

This study evaluates how in vitro digestion of meat and soy proteins differs under gastrointestinal conditions mimicking elderly achlorhydria compared to adults, showing reduced hydrolysis and distinct protein degradation patterns in elderly conditions.

This study uses omics approaches to show Hematodinium parasites modulate crustacean immune responses through miRNA and proteomic changes.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study uses a coarse-grained model to investigate the biophysics of lipid droplet formation, showing that membrane rigidity and asymmetric tension influence TG nucleation and budding direction.

The paper analyzes the transcriptome of SARS-CoV-2 naive and recovered individuals vaccinated with inactivated vaccine to understand immune response mechanisms and vaccine effectiveness.

This study shows that total parenteral nutrition (TPN) causes glucose metabolism disorders by altering gut microbiota and its metabolites, as demonstrated through human and mouse models.

This study identifies RAS/PI3K pathway activation as a common driver in oncogene-negative lung adenocarcinomas and shows these tumors are vulnerable to targeted therapy.

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

This study shows that Esm-1 reduces albuminuria and podocyte injury in diabetic mice, possibly through inhibiting interferon signaling.

This study identifies PLATZ4's role in enhancing drought tolerance and ABA sensitivity in Arabidopsis by suppressing PIP2;8 and upregulating stress-related genes through interaction with AITR6.

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

This study uses a semi-synthesis approach to generate N-terminal acetylated HMGB1 proteins and shows that this modification affects its interaction with heparin and stability.

This study investigates how cockroaches adjust their body and appendages to traverse cluttered obstacles, finding that leg sprawl reduction significantly lowers the energy barrier for locomotor transitions.

This study uses multiscale modeling to show how proton flux drives the conformational changes and ligand transport in proton-coupled peptide transporters.

The paper introduces a terrain treadmill to study animal locomotion through large obstacles over large spatiotemporal scales with high-resolution observations.

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

The paper identifies OsSWEET11b as a rice gene involved in male fertility and susceptibility to bacterial leaf blight, showing its role in sucrose transport and Xoo virulence.

The paper identifies miR-106b-5p in exosomes from Mtb-infected macrophages that promote Mtb survival by regulating lipid metabolism and apoptosis in uninfected macrophages.

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.