C. Zhao

This study uses molecular dynamics simulations to explain how ABA activates and causes dissociation of dimeric PYL2 receptors and their interaction with HAB1 phosphatase.

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

The paper characterizes 44 Arabidopsis UMAMITs, showing their localization and function as amino acid exporters, providing insights into their evolutionary role and transport properties.

This paper develops a PET probe for subtype-selective V1A receptor imaging in peripheral organs, showing high affinity and selectivity for V1A over other vasopressin receptors.

The paper shows that inhibiting HSP90 reduces STAT3-mediated muscle wasting in cancer cachexia by disrupting the HSP90/STAT3/FOXO1 axis.

The paper shows that CSP reduces ATG levels via ubiquitination by NEDD4, enabling EEFs to evade IFN-gamma-mediated killing in hepatocytes.

This paper demonstrates that SHIVs with bulky aromatic amino acid substitutions at Env375 replicate efficiently in rhesus macaques and can be used for preclinical HIV vaccine testing.

This study uses fMRI to show that amblyopia causes layer-specific changes in subcortical visual pathways, with reduced feedforward signals in the geniculostriate pathway and altered feedback signals in the retinotectal pathway.

This study identifies serum sphingolipids associated with insulin sensitivity using lipidomics and glucose clamp techniques, finding SM/Cer and SM d18:0/26:0 as potential biomarkers.

This paper introduces PlantU-net, an end-to-end segmentation network for maize seedling phenotyping from top-view images, achieving high accuracy with minimal training data.

This study shows that silencing LdCPR in Colorado potato beetles increases imidacloprid susceptibility, reduces fecundity, and causes embryonic lethality.

This study examines how smart glass affects stomatal sensitivity in Capsicum plants by altering light conditions, finding that light intensity is more critical than spectral quality for stomatal responses.

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

This paper shows HCMV drives WDR5 to the virion assembly compartment to facilitate virion assembly, expanding its role beyond nuclear egress.

This study identifies potent human neutralizing antibodies against SARS-CoV-2 from convalescent patients, with some showing high efficacy in blocking viral entry.

This paper develops a rapid, low-cost method to detect and quantify SARS-CoV-2 virus particles using nanoplasmonic sensors in microplate readers and smartphone devices.

This study uses molecular simulations to predict the structure of AtROP11 and AtABI1 complex and identifies key residues for their interaction, revealing the mechanism of ABA signaling regulation.

This study investigates how syndecan-1 mechanical tension responds to substrate stiffness and fluidic shear stress in endothelial cells.

The paper identifies and analyzes MATE transporter genes in wild chickpea species under aluminum stress, finding that CaMATE2 is upregulated in all lines while CaMATE1 is upregulated in most, correlating with root growth responses.

The paper determines the cryo-EM structure of phosphorylated α-synuclein fibrils at Tyr39, revealing structural changes linked to Parkinson's disease pathology.

This study identifies direct kinase targets of Compound Danshen Dropping Pills using literature, public databases, and in silico models, finding 30 targets at 25 g/ml and 9 dose-dependent targets at 250 g/ml.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study shows that anethole dithiolethione improves liver fatty acid metabolism in hamsters on high-fat diets by altering fatty acid profiles and regulating key metabolic pathways.

This study identifies aberrant GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe 2019-nCoV patients, linking them to immune damage and mortality.

This study determines the cryo-EM structure of a novel α-synuclein fibril formed by the E46K mutation, showing structural changes and altered stability compared to wild-type fibrils.

The paper identifies MLF2 as a component of nuclear envelope blebs and shows that Torsin ATPases are essential for completing nuclear pore complex biogenesis in interphase.

This study investigates the molecular mechanisms of brassinosteroid binding to the BRI1 receptor using molecular dynamics simulations, revealing differences in binding affinity and conformational changes between two bioactive BRs.

This study identifies GT198 mutations in stromal cells as a common cause of prostate and bladder cancers and suggests GT198 as a therapeutic target.