C. Zhao

This study compares urine proteomes of tumor-bearing mice with those of tumor-resected mice to assess resection completeness.

The paper identifies pre-treatment immune signatures associated with immune-related adverse events (irAEs) in thymic cancer patients receiving checkpoint inhibitors using CITE-seq.

This study develops a DNA extraction protocol (LPQ) that achieves saturated cell lysis for microbiome analysis, outperforming existing methods in detecting microbial differences.

This paper identifies a NOTCH1-SIRT1-KAT7 axis in T-ALL that promotes leukemia and resistance to therapy, suggesting new therapeutic targets.

The paper reports the in situ structure of SARS-CoV-2 Delta variant virions and captures membrane fusion snapshots, revealing unique architectural features and fusion mechanisms.

This study shows that 14-3-3ζ regulates insulin secretion in pancreatic β-cells by enhancing mitochondrial function and ATP synthesis, with implications for diabetes.

This study identifies climate-driven factors shaping nematode diversity in forest soils across different climatic zones.

This paper introduces a heat-shock protocol for wheat transformation that significantly improves efficiency using BBM-WUS, reducing the time to obtain transgenic plants to 60 days.

The paper develops a platform for multi-scale molecular imaging and phenotyping of the human brain, integrating novel tools for tissue processing, imaging, and computational reconstruction.

This study identifies urine proteome changes in a rat model of simvastatin-induced skeletal muscle injury, highlighting potential biomarkers for SAMS.

This study identifies the wheat gene TaD11-2A, which regulates grain size and root length, and shows its favorable haplotype improves grain yields and salt tolerance in wheat.

This study shows IDH3B is essential for spermiogenesis but not retinal health, as Idh3b-knockout mice are infertile but have normal vision.

This study identifies hedgehogs as the major amplifying hosts of SFTSV, showing they can sustain viral transmission cycles with ticks in both laboratory and natural settings.

This study identifies ACE2 as the receptor for NeoCoV and PDF-2180-CoV, two close MERS-CoV relatives in bats, showing they can use bat ACE2 and, with mutation, human ACE2.

The paper uses GSVA and AI to identify a gene set and immune signals associated with poor prognosis in HBV-related diseases.

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

This study shows pVHL regulates TCF/LEF protein stability via ubiquitin-independent proteasomal degradation, revealing a novel mechanism in Wnt/β-catenin signaling.

This study uses molecular dynamics simulations to show that water displacement at plant hormone receptor binding sites affects binding free energy and provides insights for agrochemical design.

This study shows that Malus baccata contributes to the genomes of cultivated European and Chinese apples through gene flow, alongside Malus sylvestris and Malus sieversii.

This study shows that late gestation transient prenatal hypoxia in mice leads to long-term functional deficits without gross anatomical brain damage.

This study examines age-related cellular changes in the rotator cuff enthesis of rats, finding increased mineralization and reduced tenogenic and chondrogenic potential in aged cells.

This study identifies a γδ IEL hyperproliferative phenotype influenced by the intestinal microbiota, which enhances protection against bacterial infection.

The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.

The paper reports cryo-EM structures of human TMEM120A and TMEM120B, revealing similar dimeric assemblies but no structural basis for their differing mechanosensing properties.

This paper characterizes a glycolipid glycosyltransferase (GTcp) from Candidatus Pelagibacter sp. HTCC7211, showing its broad substrate specificity and role in glycoglycerolipid synthesis under phosphorus stress.

The paper develops a synthetic infection microbiome model to show antibiotics can drive expansion of rare pathogens through competitive release in chronic infections.

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

This study shows TRAF2 regulates mitophagy and inflammation in cardiac myocytes to prevent cell death and maintain homeostasis.

This paper develops and characterizes SARS-CoV-2 RBD-specific alpaca nanobodies, showing improved binding affinity and neutralizing potency through bivalent engineering.

This paper shows that Pseudomonas aeruginosa produces novel glycolipids under phosphorus stress, which protect it from polymyxin B antibiotic.