D. Zhou

This study shows that intestinal VDR protects against dysbiosis and tumorigenesis by modulating the JAK/STAT pathway through microbiome interactions.

This study examines the effect of insulin therapy on OCT/A measurements in diabetic patients without retinopathy, finding thinner MCT and lower PVD in insulin users.

This study creates a chimera of diphtheria toxin and TPP1 to enhance lysosomal enzyme delivery, showing improved uptake and efficacy in a mouse model.

This study identifies a PAF1C-dependent pathway that restores transcription elongation after DNA damage repair in human cells.

This paper develops an anti-MUC1 antibody-drug conjugate targeting a GSTA glycosite-signature epitope, showing potent antitumoral efficacy and low toxicity in NSCLC models.

This study shows that reducing SIRT2 rescues GARS-induced neuropathy in a Drosophila model by restoring acetylated tubulin levels and axonal transport.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

This study shows that NKT cells from HIV-1 infected patients can be expanded and produce antiviral cytokines when stimulated with ex vivo dendritic cells loaded with alpha-galactosylceramide, except in advanced AIDS patients.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

The paper develops a method to detect minimal length isomeric glycopeptide neoantigen epitopes of MUC1 using pronase digestion and LC-MS, distinguishing them by MS/MS patterns and elution profiles.

This study generates triple knockout mice lacking Fut1, Fut2, and Sec1 to deplete H antigen, finding normal development and fertility despite the absence of the antigen.

This study determines how many samples are needed to accurately infer clonal mutations in heterogeneous tumors by optimizing sampling strategies.

This study uses mathematical models to investigate how de-differentiation can be an adaptive mechanism in cellular hierarchies, deriving thresholds for its emergence based on hierarchy properties and de-differentiation patterns.

The paper analyzes genomic data from 1,103 Vibrio parahaemolyticus isolates to show recent genetic mixing among four populations due to increased human-mediated dispersal.

This study shows that methylthioadenosine (MTA) reduces Salmonella virulence by suppressing flagellar and SPI-1 networks, leading to decreased motility, pyroptosis, and inflammation in mice.

The paper reports the cryo-EM structure of an early pre-60S ribosome intermediate, revealing a half-assembled subunit and key assembly factors involved in rRNA domain joining.