D. Zhou

This study identifies alveolar macrophage reprogramming by ECP that reduces TGF-β bioavailability and prevents BOS by inhibiting CCR2+ monocyte-driven inflammation.

The paper identifies piperlongumine as a covalent E3 ligase recruiter that, when conjugated with CDK9 inhibitors, induces targeted protein degradation of CDK9 and EML4-ALK fusion oncoprotein.

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

The paper identifies IL-7Rα as a key autophagosomal cargo in proliferating CD4+ T cells using a transgenic mouse model with LC3 proximity labeling.

This study shows that Omicron-B.1.1.529 has extensive mutations in Spike that reduce neutralization by antibodies from vaccinated and previously infected individuals, and escape most monoclonal antibodies.

This study shows that intranasal influenza-based boost vaccination enhances mucosal and systemic immunity against SARS-CoV-2, effectively preventing infection in both upper and lower respiratory systems.

The paper presents Cryo-EM structures of ABCD1 in different conformational states, revealing how ATP and substrate binding regulate its transport mechanism and disease-related mutations.

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

The paper identifies ERN1, a G-lectin receptor kinase, as a negative regulator of Arabidopsis immunity against root-knot nematodes by suppressing defense responses.

The paper investigates how genetic variants in the ACE2 gene affect susceptibility to SARS-CoV-2 infection by analyzing their impact on viral entry.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

This study shows that SARS-CoV-2 Nsp14 activates NF-κB signaling and increases IL-8 expression, which is confirmed in infected cells and lung tissue from COVID-19 patients.

This study identifies ELOF1 as a factor that promotes transcription-coupled repair and prevents genome instability by modulating transcription and recruiting repair factors.

The paper identifies three plasmid combinations that enhance the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China through genomic and epidemiological analysis.

The paper designs chimeric antisense oligonucleotides that degrade SARS-CoV-2 RNA via RNase L activation, showing twice the efficiency of classic antisense oligonucleotides and broad-spectrum antiviral activity.

This study evaluates a recombinant trimeric Spike protein vaccine with PIKA adjuvant, showing high neutralizing antibody titers and efficacy against COVID-19.

This paper develops a mucosal RSV vaccine, P-KFD1, which protects mice against RSV infection without vaccine-enhanced disease and relies on CD4+ T cell responses mediated by IFN-γ or IL-17A.

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

The study shows that soil intake in mice increases gut microbial diversity and reduces serum IgE levels, suggesting potential prebiotic effects.

This study shows that KSHV modulates polyamine biosynthesis and eIF5A hypusination to promote viral infection and oncogenesis, identifying these pathways as therapeutic targets.

The paper investigates photosynthesis-related gene expression in albino Artocarpus heterophyllus seedlings, finding down-regulated genes in pigment synthesis and photosynthesis pathways.

This study shows that inhibiting PLK1 promotes reactivation of KSHV and EBV in B-cell lymphomas, leading to cell death, and identifies PLK1 as a potential therapeutic target for HIV-positive patients.

SingleChannelNet is a deep learning model that automatically classifies sleep stages from raw single-channel EEG data, achieving high accuracy without hand-crafted features or multi-modality data.

The paper identifies species-specific genetic differences in ACE2 that determine SARS-CoV-2 entry capability and shows that humanizing these residues in koala and mouse ACE2 enables viral entry.

This paper identifies CR3022 as a monoclonal antibody that neutralizes SARS-CoV-2 by destroying its prefusion Spike conformation, suggesting therapeutic potential.

The paper identifies a lipid-binding pocket in the SARS-CoV-2 Spike that stabilizes the prefusion trimer and shields neutralizing epitopes, suggesting it as a potential drug target.

This study shows that high levels of circulating mitochondrial DNA predict severe illness and mortality in COVID-19 patients.

This study shows that deleting Srsf3 in cardiomyocytes leads to mitochondrial dysfunction, reduced survival, and cardiac remodeling in mice.

This paper identifies an antibody, EY6A, from a convalescent patient that neutralizes SARS-CoV-2 and cross-reacts with SARS-CoV-1 by binding a conserved epitope on the Spike protein.

This study identifies 2,119 proteins and 2,950 phosphosites in sepsis-induced kidney injury, revealing pathways related to metabolism, oxidative stress, and energy consumption during transition to chronic kidney disease.