I. Ramos

HYL001, a new potent TGFβ signaling inhibitor that is efficacious against microsatellite stable CRC metastasis in combination with immune checkpoint therapy in mice

This paper describes the development of HYL001, a TGFβ inhibitor that effectively combats microsatellite stable CRC metastasis in mice when combined with immune checkpoint therapy.

Bispecific antibodies with broad neutralization potency against SARS-CoV-2 variants of concern

The paper designs bispecific antibodies that retain neutralization activity against multiple SARS-CoV-2 variants, including Omicron subvariants.

The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters

The paper shows that nitazoxanide inhibits SARS-CoV-2 replication and pathogenesis in human and hamster models, and synergizes with remdesivir against multiple variants.

mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge

This study evaluates mRNA-1273 vaccine efficacy in hamsters, showing reduced pulmonary immune activation and improved disease outcomes after prime-boost vaccination.

ImmuneRegulation: A web-based tool for identifying human immune regulatory elements

ImmuneRegulation identifies human immune regulatory elements by integrating eQTLs, TF binding regions, and GWAS data to explore gene regulation in blood cell types.

Spermatoproteasome-deficient mice are proficient in meiotic DNA repair but defective in meiotic exit

This study shows that PSMA8 deficiency in mice leads to meiotic exit defects and infertility despite normal meiotic DNA repair and recombination.

Combined effect of matrix quality and spatial heterogeneity on biodiversity decline

This study examines how matrix quality and spatial heterogeneity affect biodiversity decline under agricultural intensification using a metacommunity model.