F. Stossi

SPACe (Swift Phenotypic Analysis of Cells): an open-source, single cell analysis of Cell Painting data

SPACe is an open-source tool for analyzing Cell Painting data, offering faster processing and better handling of cell-to-cell variation compared to existing software.

Pediatric human nose organoids demonstrate greater susceptibility, epithelial responses, and cytotoxicity than adults during RSV infection.

This study compares RSV infection responses in pediatric and adult nose organoids, finding pediatric organoids show greater susceptibility, cytokine response, and cellular damage.

RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories

Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct

This study compares infant and adult human intestinal enteroids, finding significant transcriptomic, morphological, and functional differences that highlight their distinct characteristics.

The human nose organoid respiratory virus model: an ex-vivo human challenge model to study RSV and SARS-CoV-2 pathogenesis and evaluate therapeutics

This paper develops a non-invasive human nose organoid model to study RSV and SARS-CoV-2 infection and test therapeutics like palivizumab.

Multiple RSV strains infecting HEp-2 and A549 cells reveal cell line-dependent differences in resistance to RSV infection.

The paper compares RSV infection in HEp-2 and A549 cells using four strains, finding subgroup-dependent gene expression differences and A549's greater antiviral response.

Identification of Celastrol as a novel HIV-1 Latency Reversal Agent by an Image-Based Screen

The paper identifies celastrol as a novel HIV-1 latency reversal agent through an image-based screen of a natural compound library.