G. Liu

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

A T cell vaccine based on conserved epitopes protects HLA transgenic mice from SARS-CoV-2 Beta variant mortality without inducing neutralizing antibodies.

This study uses capillary electrophoresis mass spectrometry to identify new isomers of inositol pyrophosphates in mammalian tissues and patient samples.

The paper uses stable isotopomers of myo-inositol to analyze the MINPP1-dependent inositol phosphate network in human cells, revealing a novel dephosphorylation branch.

This study generates genetically engineered goats expressing a domain fusion TLR2-4 receptor to enhance autophagy-dependent clearance of Staphylococcus aureus in macrophages.

This study shows that impaired hepatic autophagy worsens xenobiotic-induced cholestatic liver injury by promoting p62-Ub-IHB accumulation and suppressing FXR.

The paper identifies genotypic and phenotypic diversity among CRKP strains from individual patients' blood cultures, showing they are genetically distinct and exhibit different antibiotic responses and virulence traits.

This study uses cfMeDIP-seq to analyze cell-free methylomes in SCLC patients, identifying prognostic methylome clusters associated with biological pathways and repeat elements.

This study identifies a senescent preosteoclast secretome-COX2/PGE2 axis as a driver of metabolic syndrome-associated osteoarthritis, with selective COX2 inhibitors showing therapeutic potential.

The paper investigates how mutations in flanking regions of SARS-CoV-2 nucleoprotein epitopes affect proteasome processing and CD8+ T cell responses, finding some mutations reduce responses while others enhance them.

This paper identifies and calibrates ultrabright localizations in SMLM to improve quantification accuracy for biomolecular organization.

This study identifies Arabidopsis PFA-DSP proteins as specific inositol pyrophosphate phosphohydrolases, revealing their role in regulating these signaling molecules.

The paper uses single-cell transcriptomics to study cell fate transitions during early de novo shoot regeneration in Arabidopsis, identifying redifferentiation trajectories and regulatory factors.

This study develops an enzyme-based method to extract plant extracellular vesicles, showing higher yield and therapeutic potential compared to traditional methods.

This study examines how mechanical ventilation impacts the respiratory tract microbiota in rats, finding increased biofilm formation and dispersed microbial clustering.

This study shows that SVP interacts with TPL to repress flowering by inhibiting FT gene expression in chrysanthemum and Arabidopsis, highlighting a conserved mechanism across species.

The paper identifies SARS-CoV-2 T-cell epitope variants that reduce recognition by T-cells, highlighting the risk of immune evasion.

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

This study introduces scStereo-seq, a method for single-cell spatial transcriptome profiling in Arabidopsis leaves, revealing cell type-specific spatial gene expression gradients and developmental trajectories.

This study uses seascape genomics and ocean modeling to analyze connectivity patterns of Paramuricea biscaya in the Gulf of Mexico, finding depth-driven genetic structure and asymmetric larval dispersal.

The paper uses physical ocean models and genetic data to show that larval dispersal of Paramuricea biscaya follows westward currents and that stepping-stone dispersal connects distant populations.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This study shows MyD88 is essential for M cell differentiation in colitis and RANKL-induced conditions in mice.

This study examines gut microbiota composition in GDM patients before and after diet intervention, finding that diet affects the Firmicutes/Bacteroidetes ratio and specific taxa rather than altering the overall microbial pattern.

The paper establishes a bacterial genome and culture collection of the piglet gut microbiome, revealing new species and functional insights.

This study investigates the pharmacokinetics and biodistribution of extracellular vesicles in macaques via intravenous and intranasal routes, finding longer plasma circulation times and organ uptake with IV administration, but limited systemic distribution with IN.

This paper identifies the tetrameric assembly of AmnC as essential for NAD+ binding and enzymatic activity in 2-aminophenol metabolism.

This study shows that the N protein mutations R203K/G204R increase SARS-CoV-2 infectivity, replication, and virulence, contributing to its spread and disease severity.

The paper characterizes CD8+ T cell responses to SARS-CoV-2 across HLA alleles, showing HLA genotype influences pre-existing immunity and immune repertoire upon viral exposure.