G. Zhang

This study identifies miR-1 as a conserved microRNA in ticks that prolongs engorgement time and is differentially expressed across developmental stages.

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

This study investigates the mating system of C. tropicalis, finding that selfing reduces outbreeding depression caused by gene drive elements.

The paper shows that East Asian populations, particularly the Chinese Southern Han, have enhanced NK cell strength due to genetic admixture and natural selection of HLA class I alleles that interact with inhibitory KIR receptors.

This study screens a botanical drug library to identify inhibitors of Lassa virus entry, finding two compounds with distinct mechanisms of action.

The paper identifies GRL0617 as a non-covalent inhibitor of SARS-CoV-2 PLpro with an IC50 of 2.1 μM, supported by co-crystal and NMR data showing its mechanism of action.

The paper identifies a D-peptide that targets murine erythrocytes and reduces anti-drug antibody responses when conjugated to therapeutic proteins.

This paper shows that recombinant Bacillus subtilis spores expressing H. contortus GAPDH protect sheep from infection by boosting immune responses and reducing parasite burden.

The paper estimates the germline mutation rate in rhesus macaques and finds paternal age correlation, male contribution dominance, and divergence time implications for primate phylogeny.

This study identifies integrin activation and apoptosis as the mechanism of rapid platelet clearance after cold storage and shows that EGTA treatment enables cold storage of platelets for transfusion.

The paper shows extracellular histones cause disseminated intravascular coagulation (DIC) via tissue factor-dependent lytic cell death, independent of inflammasome or TLR pathways.

The paper analyzes genomic changes in white rhinoceros subspecies before and after population declines, finding reduced genetic diversity and increased inbreeding in both.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

This study compares two IDO1 inhibitors, showing GSK5628 selectively inhibits apo-IDO1 by competing with heme, while epacadostat binds to the heme cofactor, leading to longer-lasting inhibition.

This study examines gene and protein dynamics during metamorphosis in Pacific oyster Crassostrea gigas using transcriptomics and proteomics, revealing distinct gene regulation networks at different stages.

This study investigates ACE2 N-terminal fragments binding to SARS-CoV-2 Spike RBD using molecular dynamics simulations and peptide synthesis, finding that a 23-mer peptide fragment binds with micromolar affinity to insect-derived RBD but not HEK-expressed RBD.

This study analyzes microsatellite dynamics across ancient and modern genomes to show they maintain a stable length distribution over time despite individual variability.

This study identifies circ_0005962 as an oncogene in NSCLC that promotes progression via the circ_0005962/miR-382-5p/PDK4 regulatory network.

The paper introduces a method to estimate stain density in electron microscopy by using bright-field intensity ratios and section thickness measurements.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study shows that the C-linker in BK channels modulates activation through nonspecific membrane interactions, challenging previous assumptions about its role.

The paper shows that the TYLCV protein V2 suppresses viral genome methylation in plant Cajal bodies by interacting with AGO4.

The paper investigates the origin and evolution of A-to-I RNA editing in metazoans, finding it emerged in the common ancestor and is nonadaptive in most regions except for specific taxa.

The paper uses dual electron probes to study ferritin distribution in human erythropoietic stem cells during differentiation, finding increased Fe3+ accumulation in lysosomal ferritin cores.

This study identifies Plasmodium α-tubulin-1 as a binding partner of Anopheles FREP1, showing that anti-α-tubulin antibodies inhibit malaria transmission to mosquitoes.

The paper uses SBEM to determine secretory granule maturation times in mouse pancreatic beta-cells, finding immature granules remain in their state for about 2 hours before transforming.

The paper develops an approach to analyze evolutionary forces on genomic regions linked to preterm birth and finds diverse signatures like negative and positive selection.

The paper identifies endogenous foamy viruses in two stork species, showing independent integration events in birds and expanding the known taxonomic distribution of foamy viruses.

This study compares the gut microbiome of short-term and long-term medical workers to normal controls, finding significant structural changes linked to hospital exposure.

This study evaluates how different nitrogen fertilizer rates affect tuber yield and processing quality of two potato cultivars, finding optimal rates for high yield and quality.