G. Zhang

This study investigates sex chromosome evolution in paleognath birds, finding that tinamous have higher substitution rates and unique evolutionary strata without chromosomal inversion.

The paper identifies JMJD6 as a protease that cleaves MePCE, releasing P-TEFb from the 7SK snRNP complex to enable Pol II-CTD phosphorylation.

The paper samples Hawaiian C. elegans strains, revealing high genetic diversity and admixture with global populations, suggesting ancestral diversity preserved in Hawaii.

This study compares the hypocholesterolemia effects of four probiotic strains with atorvastatin in a high-fat diet model, showing probiotics are less effective but alter gut microbiota differently.

This study shows that p16 suppression increases nucleotide synthesis through mTORC1 activation, promoting tumorigenesis by bypassing senescence.

This study shows that climate change has caused a northward shift in the range of wheat pests, leading to increased crop damage despite pesticide use.

This study shows oleocanthal and oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells, reducing tumor burden and extending lifespan in mice.

This study identifies RHAMMB as a key driver of pancreatic tumor metastasis, showing its upregulation in PNETs and correlation with poor patient survival through EGFR signaling.

The paper identifies hypoxia and drug-induced translational activation of NANOG, SNAIL, and NODAL isoforms that drive breast cancer plasticity and stem-cell-like phenotypes, with potential therapeutic implications.

The paper identifies 196 differentially expressed proteins in TGF-β1-treated lung fibroblasts and finds that VLDLR and SDC2 are upregulated in silica-exposed lungs, with knockdown reducing collagen production.

This study shows that vitamin A supplementation after neonatal Streptococcus pneumoniae pneumonia reduces allergic asthma in mice by altering CD4+ T cell subsets.

This study identifies two FDA-approved drugs, lacidipine and phenothrin, as Lassa virus entry inhibitors through high-throughput screening and mechanistic analysis.

This study shows that PLEKHO1 in osteoblasts worsens joint inflammation in RA and promotes bone formation, suggesting it as a therapeutic target.

This study shows Cdc20 and C-Mad2 levels correlate at kinetochores and that Cdc20 depletion reduces Mad2 levels, suggesting Mad2-Cdc20 complexes exist at kinetochores.

The paper predicts synthetic rescue mediators of resistance to targeted and immunotherapy using tumor transcriptomics and survival data from 10,000 TCGA patients, validating predictions through experimental screens.

This study shows that C24 sphingomyelin in the outer leaflet suppresses membrane microdomains by directing cholesterol to the inner leaflet, while C16 sphingomyelin promotes microdomains.

The paper identifies BAM1 as a positive regulator of RNAi cell-to-cell spread and shows that a viral protein inhibits this process by interacting with BAM1 and BAM2.

The paper sequences the genome of a diabetes-prone desert rodent and identifies a mutation hotspot around the ParaHox gene cluster, including the Pdx1 gene, showing extreme divergence due to GC-biased mutation.