H. Yan

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

This study shows BTKi treatment reduces APOBEC3 expression in CLL B cells through enhancer regulation, linking BCR signaling to genomic instability.

This study examines the distribution of transcriptional outputs in Myc-amplified medulloblastoma cells and identifies IMPDHs as a therapeutic target.

The paper investigates how protein secondary structure affects glycan clustering in native mass spectrometry, finding that β-sheet content strongly influences clustering behavior.

This study identifies key genes and regulatory networks in flavonoid metabolism of Rosa roxburghii using transcriptome analysis and WGCNA.

This study experimentally examines how toehold length, location, and mismatches affect strand displacement kinetics in RNA and RNA-DNA hybrid systems.

This study identifies FlbA1 and FlbA2 as regulators of fumonisin B1 biosynthesis in Fusarium verticillioides, showing FlbA2 inhibits FB1 production while FlbA1 has no significant effect.

This study sequenced and compared the genomes of two Sphingomonadaceae strains, revealing shared lutein synthesis genes and unique genes for hepatotoxin degradation in Sphingopyxis USTB-05.

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

This study investigates the functions of Mediator subunits in Fusarium verticillioides, showing that some subunits have unique regulatory roles in development, stress response, and secondary metabolism.

This paper develops a mucosal RSV vaccine, P-KFD1, which protects mice against RSV infection without vaccine-enhanced disease and relies on CD4+ T cell responses mediated by IFN-γ or IL-17A.

This study shows Bub1 and the CENP-U complex redundantly recruit Plk1 to kinetochores, ensuring accurate chromosome segregation, and suggests potential therapeutic targets for cancer cells with Bub1 or CENP-U mutations.

This paper introduces PlantU-net, an end-to-end segmentation network for maize seedling phenotyping from top-view images, achieving high accuracy with minimal training data.

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This study uses HDX-MS to analyze glycan-induced structural dynamics in norovirus P dimers across strains and deamidation states, revealing strain- and deamidation-dependent changes in protein flexibility and solvent exposure.

This study reevaluates Spinach-based RNA visualization in plants, showing potential for ex vivo and in vivo RNA monitoring.

This paper identifies PI3K pathway activation as a driver of metastatic progression in pancreatic cancer and shows that targeting PI3K can delay macro-metastatic evolution.

The paper shows that many bat species cannot host SARS-CoV or SARS-CoV-2 due to ACE2 receptor incompatibility, with genetic analysis identifying restrictions to viral entry.

This study identifies ZNF416 as a key transcriptional regulator that mediates fibroblast responses to matrix stiffness through chromatin accessibility and gene expression changes.

The paper investigates nevus growth arrest using a mouse model and finds that collective cell behavior, not cell-autonomous senescence, explains nevus size control.

This study identifies SARS-CoV-2's high fusogenic activity via ACE2 receptor and designs a potent lipopeptide inhibitor, IPB02, targeting the HR2 region of the spike protein.

B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.

This study shows that antibodies from SARS-CoV survivors and immunized animals neutralize SARS-CoV-2, suggesting potential for broad-spectrum vaccines against emerging coronaviruses.

This study investigates how loop extrusion factors and chromatin structure influence chromatin dynamics using microscopy, genetics, and simulations in fission yeast.

This study investigates the immune response of macrophages to mucin hydrogels, showing sialic acid-dependent activation of cytokines and markers, with effects diminishing by day 7.

This study identifies and characterizes FvGbb2, a putative G{beta}-like protein in Fusarium verticillioides, showing its role in fumonisin biosynthesis, growth, and stress response.

This paper identifies FvLcp1, a secreted type-D fungal LysM protein with chitin-binding domains, as a key factor in fumonisin production and host recognition in F. verticillioides during maize infection.

This study shows that FvSec4 is essential for hyphal development, virulence, fumonisin B1 production, and stress response in Fusarium verticillioides.

This study develops mucin hydrogels that reduce fibrotic encapsulation in vivo by modulating immune responses, showing reduced fibrosis and immune cell recruitment compared to alginate hydrogels.