H. Zhang

This paper develops data-informed strategies to design hydrolytic nanozymes with enhanced catalytic activity and broad substrate specificity.

This study links CD44-/CD24- breast cancer cells to late-stage tumor recurrence and identifies RHBDL2 as a regulator of CSC conversion.

The paper shows that ACE2-expressing exosomes in plasma block SARS-CoV-2 infection by competing with cellular ACE2, offering a new innate antiviral mechanism.

This study uses experimental evolution to identify 35 mutations in 28 genes that enhance Pseudomonas protegens' ability to colonize the Arabidopsis thaliana rhizosphere.

This study links antigen responsiveness, proviral sequences, integration sites, and TCRβ sequences to show antigen-driven clonal selection maintains HIV-1 persistence in CD4+ T cells.

This paper introduces non-uniform refinement, an adaptive regularization method for single particle cryo-EM that improves 3D reconstruction resolution and quality by accounting for spatial variability in macromolecular structures.

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.

This study links Prochlorococcus genome reduction to the Neoproterozoic Snowball Earth climate event, showing how extreme conditions drove metabolic adaptations.

This study analyzes fecal microbiota composition in CRC patients and identifies Fusobacterium as a potential biomarker for CRC screening in Chinese populations.

The paper develops a genomic resource of 1,500 soybean genomes with 32 million SNPs to enable post-genomic research and applications like QTL discovery and trait allele identification.

This study presents the structure of primate ferroportin and elucidates its mechanism of iron transport and regulation by hepcidin.

This study profiles cfDNA and exosomes from an astronaut during a year-long spaceflight, identifying increased cf-mtDNA and exosomal brain-derived peptides as potential biomarkers of spaceflight-related stress.

This paper introduces a dual-stage deep-learning network to enhance 3D fluorescence microscopy resolution and throughput, achieving faster imaging with improved contrast and subcellular detail.

This study shows E-cadherin interacts with EGFR to hyper-activate ERK, promoting proliferation in breast cancer models and identifying a potential therapeutic target.

This study investigates how light intensity affects the coloration and structure of chimeric leaves in Ananas comosus var. bracteatus, finding that 50% shade optimizes growth and ornamental value.

This study shows that dysfunction of IBM1 in Arabidopsis changes root-associated bacteria communities by altering microbial family abundances in both rhizosphere and endosphere.

The paper investigates cross-reactivity between mugwort and house dust mite allergens, finding that mugwort tropomyosin induces a non-Th2 response in allergic rhinitis patients.

The paper shows tobacco carcinogens increase ACE2 mRNA but reduce ACE2 protein levels via Skp2-mediated ubiquitination, decreasing SARS-CoV-2 infection in lung cells.

The paper investigates the ftin gene's role in wheat under cold stress, finding it inhibits spike development through multiple pathways and phenotypic changes.

This paper develops a system to measure sub-second heat inactivation of coronavirus and identifies conditions achieving >5 Log10 viral titer reduction.

The paper develops a UPLC-SRM MS method to quantify B vitamins in lentils, finding a 1.5-fold increase in total B vitamins during germination with vitamin B5 as the most abundant.

This study investigates how platelet-activating factor (PAF) affects the barrier function of ARPE-19 cells by altering tight junctions and VEGF expression.

The paper identifies a mechanism of REC protein family expansion through gene recombination and positive selection, leading to functional divergence in bacterial response regulators.

This study evaluates the impact of preoperative α-blocker use on outcomes in extra-adrenal retroperitoneal paraganglioma surgeries, finding no significant differences in postoperative complications.

This study identifies CVB3 VP1 as an inhibitor of cell proliferation by disrupting MAT1 interaction with the CAK complex, thereby blocking CAK-CDK4/6-Rb signaling in pancreatic cells.

This study identifies miR775 as a regulator of leaf size in Arabidopsis by silencing GALT9, a galactosyltransferase that affects cell wall pectin levels and elasticity.

This study investigates how different doses of glycerol monolaurate (GML) affect gut microbiota and metabolic syndrome in low-fat diet-fed mice, showing high-dose GML reduces MetS through microbiota changes.

This study identifies a Krt5-BMP4 mechanosignaling pathway that regulates histone modifications and blastema cell remodeling during zebrafish heart regeneration.

This paper reclassifies Saccorhytus coronarius as an early Cambrian ecdysozoan lacking an anus, challenging previous deuterostome interpretations.