H. Zhang

This paper identifies and characterizes the NIC1-locus in tobacco, showing it regulates nicotine biosynthesis through ERF genes that function downstream of NtMYC2 in the JA signaling pathway.

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

The paper investigates how the HD-ZIP IV transcription factor mutant ocl4 affects 21-nt phasiRNA accumulation in maize anthers under different environmental conditions, finding that these phasiRNAs buffer development under stress.

The paper demonstrates that RAS proteins can be degraded using bioPROTACs and provides insights into the functional consequences of RAS degradation and mutant susceptibility.

This study assesses the effectiveness of riverine water eDNA for monitoring aquatic and riparian biodiversity, finding it effective for detecting species and bioinformation in specific conditions.

This study introduces a statistical method to analyze mutation dynamics in influenza A H3N2, showing regional mutation contributions to global epidemics and identifying key amino acids for therapeutic targets.

The paper develops a comparative modeling approach to study CDK9 inhibitor selectivity and structure-activity relationships, using existing PDB data and validating with a crystal structure.

This study compares two dietary models of murine NAFLD/NASH, showing differences in metabolic syndrome and liver disease severity, but similar tumour burdens in liver cancer models.

The paper shows that Aurora B kinase activity leads to kinetochore-microtubule release under high tension and depolymerization under low tension, suggesting tension-dependent error correction mechanisms.

This study shows that spermidine maintains autophagy in aged human T cells, improving vaccine responses by enhancing IFN-gamma secretion and T cell function.

This paper describes a project-oriented learning system at Taishan Medical University that uses reverse genetics to enhance undergraduate students' understanding of biochemistry and molecular biology through hands-on laboratory experience.

This study shows RADX condenses single-stranded DNA and blocks RAD51 loading, revealing its role in regulating DNA replication and repair.

This study shows that Dicer-like 5 deficiency in maize leads to temperature-sensitive male sterility and defects in anther development.

The paper shows that dual localization of WHIRLY1 affects salicylic acid homeostasis by regulating ICS1, PAL1, and BSMT1 during Arabidopsis aging, leading to altered senescence phenotypes.

A hidden layer of host immunity against non-pathogenic microbes leads to plant incompatibility with beneficial rhizobacteria.

The paper uses a HOXA9-mCherry reporter and CRISPR/Cas9 screens to identify USF1/USF2 as regulators of HOXA9 in MLLr leukemia, showing their role in leukemia cell proliferation.

This study investigates abortion rates and risk factors in dairy cows and sheep in Ili, China, identifying Brucella melitensis as the main pathogen and highlighting management factors contributing to reproductive issues.

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

The paper investigates how HetR controls gene expression from DIF1 motif promoters during heterocyst differentiation, showing dependence on HetZ and modulation by PatU3.

This study uses scRNA-seq to identify and characterize subtypes of human BM-MSCs in vivo, revealing their heterogeneity and potential differentiation trajectories.

This paper introduces a novel MRI/MRS method that selectively images specific metabolites by using nuclear spin singlet states, demonstrating molecular selectivity for endogenous molecules like N-acetylaspartate and dopamine.

This study analyzes plastome sequences from Gentianeae to show gene tree discordance and evolutionary rate heterogeneity among plastid genes, suggesting the need for more nuanced phylogenomic approaches.

The paper models the kinetics and steady-state degradation of target proteins by autophagosome tethering compounds (ATTEC), showing how binding affinities affect degradation efficiency.

The paper investigates SARS-CoV-2 infection in cats by detecting serum antibodies, finding 14.7% of post-outbreak samples positive for RBD and 11 with neutralizing antibodies.

The paper develops CAR-expressing iPSC-derived macrophage cells with antigen-dependent anti-cancer functions effective against both liquid and solid tumors.

This study classifies and analyzes the expression of heat shock proteins in wheat infected with powdery mildew and stripe rust, revealing structural diversity and differential expression patterns.

The paper determines the crystal structure of the MBTD1-EPC1 complex, revealing the molecular mechanism of MBTD1 recruitment into the NuA4/TIP60 acetyltransferase complex.

The paper identifies a pathway for repairing TOP3B DNA and RNA cleavage complexes, showing that TDP2 excises ubiquitinated TOP3Bccs after proteasomal degradation.

Click-ExM expands super-resolution imaging to all biomolecules by integrating click-labeling into expansion microscopy.