J. Chen

This study shows that microbubble-mediated cavitation induces apoptosis and reduces invasion in AsPC-1 cancer cells through increased calcium, cleaved Caspase-3, BAX, and decreased Bcl-2, HIF-1, and Vimentin.

This study uses single-cell RNA-seq to analyze keloid tissue and identifies lineage-specific regulatory changes in fibroblasts and vascular endothelial cells, highlighting key pathways and potential therapeutic targets.

This study identifies ARTS as a p53-responsive gene that promotes mitochondrial apoptosis by interacting with p53 and enhancing its pro-apoptotic effects.

This study shows that EphA2 overexpression in NSCLC tumors reduces T cell infiltration and increases myeloid suppressor cells, promoting immune evasion.

This study determines the structure of the mammalian PA28β-iCP immunoproteasome using cryo-EM, revealing a unique mechanism of proteasome activation distinct from constitutive proteasomes.

This study identifies HK2 as a marker for detecting underrepresented CTCs in NSCLC, revealing a distinct subpopulation with unique characteristics.

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

This study shows that NPM1 regulates macrophage function through rRNA 2'-O-methylation and translation control, revealing a role in immune cell activity.

This study shows that prenatal arsenic exposure in mice leads to transgenerational impairments in spermatogenesis, associated with epigenetic changes in Igf2 and H19.

This paper presents a CAD system for pulmonary nodule detection that improves recall, reduces false positives, and optimizes time consumption using a multi-model ensemble approach.

This paper introduces a reagentless sensor that detects molecular analytes in biological fluids by measuring directional diffusion of a nanoscale molecular pendulum and electron-transfer kinetics.

This paper introduces a new gene-delivery method using magnetic nanoparticles and ultrasound, achieving higher transfection efficiency with lower toxicity than conventional techniques.

This study examines how training-induced changes in sarcomere number affect residual force enhancement and depression in rat muscles, finding no significant impact on force magnitude.

This study identifies novel ISGylation targets regulated by USP18, showing its role in enhancing tumour cell antigenicity and reducing radiosensitivity in CML cells.

The paper analyzes CD45 isoforms in T cells from liver cancer patients to show their role in T cell heterogeneity and function.

This study investigates how water depth and light conditions affect the morphology, physiology, and resource allocation of Vallisneria natans, showing shifts in resource allocation between light acquisition and reproduction.

This study shows that high concentrations of angiotensin II induce apoptosis in human iPSC-derived cardiomyocytes after long-term exposure.

This study shows that LZTR1 inactivation in glioblastoma stabilizes RIT1, leading to MAPK/ERK pathway activation and promoting tumor growth.

This study shows microampere electric currents cause bacterial membrane damage and two-way leakage within 30 minutes.

This paper shows that HCFC1 and HCFC1R1 deficiencies block HSV-1 infection by inhibiting nuclear translocation of HCFC1 and VP16, offering potential new therapeutic targets.

This study shows that malignant B-cell transformation requires convergence on a single oncogenic pathway, while divergent pathways can subvert transformation and are targets for new therapeutic strategies.

The paper compares glycome and lectin gene expression between resident and elicited macrophages, finding differences in glycan types and lectin gene expression.

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

This study shows ARHGEF3 promotes muscle regeneration and strength by enhancing autophagy, independent of mTORC2-Akt signaling, in both young and aged mice.

This study investigates how silver ions inhibit bacterial motility by affecting flagellar motor function in E. coli, showing reduced swimming speed and altered tumbling behavior.

This study analyzes pangolin coronaviruses to assess their role as potential intermediate hosts of SARS-CoV-2, finding genetic relatedness but not direct origin.

This study identifies a novel role for sphingosine kinase 2 in the metabolism of sphinga-4,14-diene lipids, showing that its absence leads to their accumulation in the brain due to slower catabolism.

This study shows that the C-linker in BK channels modulates activation through nonspecific membrane interactions, challenging previous assumptions about its role.

This study shows glycolysis is essential for CD8+ T-cell effector function, while mitochondrial respiration is not, and inhibiting glycolysis reduces autoimmunity in a diabetes model.

The paper investigates exosome-mediated apoptosis during WSSV infection in mud crabs, identifying miR-137 and miR-7847 as negative regulators of apoptosis by targeting AIF.