J. Hu

This study shows ANKRD49 promotes metastasis in NSCLC cells by activating the JNK-ATF2/c-Jun-MMP-2/9 pathway.

This study identifies how HBV alters PP2A complexes to drive liver cancer signaling, revealing potential therapeutic targets.

This study shows that O-GlcNAcylation regulates NF-L assembly and function, and CMT mutations disrupt this process, linking glycosylation defects to neurodegeneration.

This study shows that EETs and sEH inhibitors prevent CVB3-induced myocarditis by enhancing type I interferon signaling and improving viral resistance.

This study shows TERT promotes thyroid cancer dedifferentiation and progression by enhancing ribosome biogenesis, and inhibiting rRNA synthesis can reverse this process.

This study shows that loss of WNT5A and WNT5B in mice protects against DSS-induced colitis by reprogramming spleen neutrophils to suppress inflammation.

The paper introduces WIT, a context-aware transformer model for whole slide image classification, achieving higher accuracy than baseline methods across multiple cancer datasets.

This study uses single-cell transcriptomics to profile cell cycle dynamics in two forms of Trypanosoma brucei, identifying conserved and form-specific gene expression patterns.

This study develops a method to purify human α-cells with >97% purity using a fluorescent probe, enabling functional and transcriptomic analyses.

This study identifies a Wnt/β-catenin-PTHrP negative feedback loop that maintains articular cartilage homeostasis and prevents osteoarthritis progression.

This study assesses reproducibility in high-content live cell imaging data across multiple sites and identifies sources of variability, showing that batch correction improves meta-analysis of perturbation experiments.

This paper develops an mRNA vaccine for chronic hepatitis B that shows strong immunogenicity and persistent virological suppression in mouse models.

This paper identifies and engineers a high-fidelity Cas12i variant with broad PAM recognition and minimal off-target activity for improved genome editing.

The paper shows sodium borohydride irreversibly inactivates lactate racemase by transferring hydride to the nickel-pincer nucleotide cofactor, revealing its reactivity.

This study evaluates antibody kinetics and durability after CoronaVac vaccination in health subjects, finding waning antibody levels over time and improved responses with a booster dose.

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

This paper proposes a deep learning model for multi-label bacterial classification, showing it is lighter, faster, more accurate, and efficient than existing methods.

This study uses transcriptomic analysis to examine gene expression changes in cigar leaves at different growth stages, identifying key pathways and regulatory networks associated with maturity.

The paper describes a new turtle species and investigates the function of carapace anterolateral processes using computational fluid dynamics.

This study determines the structural mechanism of a bacterial ZIP metal transporter, revealing an elevator-type transport mechanism through structural and computational analysis.

This paper identifies CSE-p53 interaction as a regulator of endothelial cell senescence and metabolic reprogramming in aging, showing that restoring this interaction can prevent senescence and promote vascular repair.

This study shows that ecological corridors increase plant root endospheric fungal species richness and reduce beta-diversity over time.

This study shows that weed species diversity and identity affect wheat root endospheric mycobiota and growth through neighbourhood effects.

This study identifies WNT4's role in regulating cancer metabolism through mitochondrial intracellular signaling in breast and gynecologic cancers, linking genetic variants to metabolic remodeling.

This study develops a multiplex CRISPR-Cas system targeting ASF virus genomic loci, demonstrating resistance in gene-edited pigs and potential applications in agriculture and biomedicine.

The paper introduces a microbial risk score (MRS) framework to aggregate microbiome data into a predictive score for disease risk, validated across multiple cohorts.

The paper maps the localization of 1,032 chloroplast proteins in Chlamydomonas reinhardtii, revealing novel structures, spatial organization, and dual-organelle targeting.

This study maps epithelial cell states and plasticity in lung adenocarcinoma using single-cell data, identifying KRT8+ alveolar intermediate cells linked to poor survival and tumorigenesis.

The paper analyzes single-cell RNAseq data from metastatic castration-sensitive prostate cancer patients treated with anti-PD-1 immunotherapy, showing increased immune infiltrate and identifying therapy-resistant tumor subpopulations and druggable targets.