J. Lee

This study identifies polybacterial intracellular co-infection in human periodontal epithelial cells, revealing its proinflammatory effects and potential role in chronic diseases.

This study identifies a novel 14-mer antiangiogenic peptide derived from prolactin that inhibits bradykinin- and eNOS-dependent angiogenesis, showing synergistic effects with Avastin in a colon cancer model.

This study derives and characterizes clonal endothelial progenitor cell lines from human embryonic stem cells, showing their scalability and functional similarity to adult endothelial cells.

This study investigates how orthosteric and allosteric ligands affect mGluR activation and desensitization using electrophysiology, imaging, and cryo-EM structures.

The paper compares implant stability measurements using RFA and DCA in different implant lengths and bone densities, finding correlations with bone density and length.

This study identifies the generation mechanism of C-rich single-stranded DNAs and C-circles in ALT cancers using a novel assay, showing their origin from Okazaki fragment processing and CST-PP complex-mediated DNA synthesis.

The paper tests nucleoside analogues for antiviral activity against orthopoxviruses, finding tenofovir and adefovir effective with low toxicity.

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

This study shows that sorafenib can prolong lung cancer response to EGFR inhibitors by targeting resistant cells' selective advantage.

The paper evaluates contezolid as a potential replacement for linezolid in combination with bedaquiline and pretomanid in a murine tuberculosis model, finding comparable activity and no cross-resistance.

The paper determines TAP structures with peptides to show how it selects peptides by length while allowing sequence diversity through terminal interactions.

This study uses single-molecule techniques to show streptolydigin induces pauses in RNA polymerase, which are enhanced by Gre factors, revealing a new mechanism for antibiotic action.

The paper identifies a capsule defect in K. pneumoniae that enhances complement-mediated opsonophagocytosis and persistence during recurrent infections.

This study identifies dietary simple carbohydrates as critical for Klebsiella pneumoniae colonization and shows dietary fiber's role in preventing its dissemination during colitis.

The paper analyzes telomeric repeat motifs in nematodes using genome assemblies and subtelomere structures to reveal evolutionary changes in TRMs.

This study uses nanopore sequencing to rapidly and accurately profile human microbiomes in saliva and stool samples, revealing insights into microbiome composition and host-microbe interactions.

The paper identifies a new RiPP subclass, pimtides, by analyzing the evolutionary spread of PIMT enzymes and their role in modifying precursor peptides.

This study shows that combining CD4+/CD8+ T cell neoantigen vaccination with immune checkpoint blockade overcomes resistance and enables tumor regression in low TMB cancers.

This study shows that FAK-mediated tension sensing in endothelial cells regulates nuclear mechanotransduction, transcriptome, and cell fate, crucial for maintaining a restrictive endothelial barrier.

The paper investigates how early-life social experiences affect adult behavior and stress responses in Astatotilapia burtoni cichlid fish, finding distinct behavioral syndromes linked to social partner numbers and group stability.

The paper investigates the role of Acinetobacter in EBPR systems using 16S sequencing and SCRS-FISH, finding Acinetobacter dominance and its contribution to phosphorus removal under specific operational conditions.

The paper demonstrates an integrated wastewater treatment process that achieves nitrite accumulation through comammox and unknown AOBs, revealing their role in short-cut nitrogen removal.

This paper demonstrates the activation of a protodrug, SQP22, using click chemistry with tumor-targeting agents, showing anti-tumor effects in murine models with reduced toxicity.

This study shows that repeated mRNA vaccination leads to BCR hypermutation, enabling antibodies to neutralize Omicron variants.

This study identifies CD25 as a scaffold for phosphatases that regulate B-cell signaling and oncogenic processes, with opposing effects on B-cell malignancies and autoimmunity.

This study identifies a unique vulnerability in B-cell malignancies where GSK3β inhibitors disrupt β-catenin-Ikaros complexes, leading to MYC repression and cell death.

This study shows that SIRT7 contributes to sorafenib resistance in HCC by enhancing ERK phosphorylation, and inhibiting SIRT7 with sorafenib reduces tumor growth.

This paper creates a biobank of patient-derived organoids to identify molecular subtypes of Crohn's disease and test subtype-specific therapies.

This study identifies oxytocin as an intestinal hormone produced and secreted by enterocytes in response to secretin stimulation by L. reuteri.