J. Lee

This paper introduces a deep learning method for label-free cell nucleus segmentation in time-lapse refractive index tomograms, validated across multiple experiments.

This study genetically characterizes mitochondrial Ca2+ uniporter components in Drosophila, revealing distinct functional roles and phenotypic outcomes of their loss.

The paper quantitatively analyzes how stochastic noise affects a gene regulatory network with positive feedback, showing that noise can lead to protein extinction despite deterministic predictions.

The paper creates a cellular atlas of the normal adult human prostate and prostatic urethra using single-cell RNA sequencing and flow cytometry, identifying two new epithelial cell types.

This study uses high-resolution 3D genome maps to identify CD276 as a therapeutic target in glioblastoma stem cells, showing it can suppress self-renewal.

This study shows that Calotropis gigantea extract induces apoptosis in NSCLC cells via extrinsic and intrinsic pathways and ROS generation.

This study uses whole-genome sequencing of cancer samples to reconstruct the evolutionary history of 39 cancer types, identifying early and late-stage mutational patterns and driver genes.

This study shows RUNX3 regulates chromatin dynamics at the restriction point by opening and closing target loci through recruitment of chromatin modifiers, influencing cell cycle progression and tumor development.

This study evaluates higher doses of rifamycins in a mouse model of Buruli ulcer, finding dose-dependent efficacy and potential for shorter treatment regimens.

The paper identifies the common ancestry of TALE homeobox transcription factors across Metazoa and Archaeplastida, showing their role in haploid-to-diploid transitions through heterodimerization.

This paper improves FRET-PAINT microscopy speed by 8-fold through optimizations in camera speed, probe dissociation, and signal bleed-through, achieving 40-nm resolution in tens of seconds.

The paper identifies a modular transcriptional signature for active tuberculosis that distinguishes it from latent infection and other diseases, showing dynamic heterogeneity in tuberculosis contacts.

This study examines the correlation between neutralization breadth and infected-cell binding of broadly neutralizing antibodies against HIV reactivated from latent reservoirs.

This study identifies DUSP28 as a biomarker that promotes metastatic pancreatic cancer progression through autocrine signaling pathways and pro-angiogenic effects.

The paper investigates how herbivore habitat preference influences plant distribution, finding that herbivores prefer sunny habitats over shade plants, driving the plant's distribution into shaded areas.

This study compares CD4+ and CD8+ T cell recognition of Mtb-infected macrophages, finding CD8+ T cells poorly recognize infected macrophages despite strong immunodominant responses.

This paper describes the engineering of a microbial pathway using a novel P450 fatty acid decarboxylase to produce odd-chain terminal alkenes from glucose, achieving a 2.8-fold increase in yield through redox system optimization.

This study evolves CRISPR-Cas9 to enhance specificity while maintaining on-target activity in human cells.

The paper identifies ANO9/TMEM16J as a cation channel activated by the cAMP/PKA pathway and shows its expression in intestinal cells.

The paper evaluates ensemble-based virtual screening for RNA targets using a high-resolution TAR RNA ensemble and shows improved accuracy over single-structure docking.

The paper reports multiple pepper genomes and finds that retroduplication via LTR-retrotransposons drives expansion of disease resistance genes in plants.

The paper identifies de-differentiated, inflammatory cancer-associated adipocytes in breast cancer and shows that miR-5112 promotes IL6 expression through targeting Cpeb1.

This study identifies a genetic variant affecting telomere length in C. elegans and finds no correlation between telomere length and fitness traits.