J. Lee

This study shows that PI4KIIIβ promotes breast cancer by regulating endocytic kinetics and Rab11a-mediated signaling through its interaction with Rab11a, independent of its kinase activity.

The paper introduces SBG-conjugated fluorophores to improve extracellular labeling of SNAP-fused proteins, enabling precise analysis of GPCR populations in living cells and tissues.

The paper shows that CLPP2 in Arabidopsis thaliana aids in coordinating and assembling protein complexes encoded by both mitochondrial and nuclear genomes, affecting mitochondrial protein homeostasis.

This study investigates how mechanical forces affect breast cancer cell behavior, finding that tension alters gene expression, increases chemoresistance, and promotes metastasis through specific signaling pathways.

This study evaluates genome-resolved metagenomics for recovering giant virus genomes, showing success at high spike-in levels but highlighting the underdetection of most giant viruses.

This study identifies Akt and MAPK signaling as essential for Tim-3 co-stimulatory activity and shows that Tim-3 localization to the immune synapse is critical for its function.

This study identifies a link between geometric features of melanoma aggregates and reprogramming to stem cell-like initiating cells through histone modifications.

The paper introduces a platform for standoff imaging of transgenic plants using fluorescent proteins, demonstrating its application in phenomics and stress response analysis.

This paper identifies the unique N-terminal region of Chlamydia MreB as critical for its membrane association and interaction with divisome components, supporting its role as a substitute for FtsZ in cell division.

This paper introduces genetically encoded phase contrast agents using gas vesicles for digital holographic microscopy, enabling tracking of bacteria and imaging of mammalian cell uptake.

The paper introduces injection molded open microfluidic devices for coculture and microscopy, enabling study of cell interactions in standard cell culture workflows.

Flg22 activates two kinase pathways that phosphorylate and degrade CAMTA3, removing it from target promoters to de-repress defense genes.

This study shows that a high-phytate/low-calcium diet causes crystal nephropathies, renal phosphate wasting, and bone loss in rats through tubular dysfunction and altered mineral absorption.

The paper presents a genome assembly of Paulinella micropora KR01 and its symbiotic bacteria to study primary plastid evolution and bacterial symbiosis.

This study identifies two residues in Kv1.2 that act as a pH switch, showing how protonation disrupts electrostatic balance and causes channel closure through dewetting of the water cavity.

This study shows that loss of BubR1 acetylation causes replication stress and complex chromosomal rearrangements in tumors.

This study shows that GV1001 reduces ovarian follicle loss caused by bevacizumab in mice without affecting its anti-cancer effects.

This study shows Shigella strains proliferate in Arabidopsis plants using type III effectors similar to their role in human infections.

The paper shows that cAMP-PKA-CREB signaling in cDC2s represses IRF4 and KLF4, promoting Th17 responses and inhibiting Th2, with similar effects observed through PRR-dependent signals like curdlan.

This paper introduces a portable microscope technique for real-time field imaging of stomatal dynamics in tomato leaves without physical or chemical manipulation.

This study shows TRAP1 forms an OXPHOS-regulated tetramer and is essential for maintaining mitochondrial metabolic homeostasis by modulating OXPHOS and interacting with mitochondrial chaperones.

This study identifies H3N2 HA RBS-targeting antibodies in humans, showing some can be broadly reactive despite sensitivity to substitutions near the RBS.

The paper identifies LSF as a facilitator of SET8-mediated α-tubulin methylation, revealing a novel role for these proteins in cytoskeletal modification during mitosis.

This paper develops a method to achieve tissue-specific genome editing in vivo using microRNA-repressible anti-CRISPR proteins to limit Cas9 activity to target tissues.

The paper analyzes RIN4/NOI fragments cleaved by AvrRpt2, revealing that the N-end rule pathway degrades NOI-domain fragments but not RIN4.

This paper develops branched photoswitchable ligands for efficient optical control and detection of class C G protein-coupled receptors, demonstrating near-complete agonism and dual imaging/manipulation capabilities.

The paper shows that arginine culture induces nitrogen starvation responses in microalgae without limiting growth or photosynthesis, leading to increased lipid droplet accumulation.

Carotenoids are not just required as core components for plastid biogenesis, they can be cleaved into an apocarotenoid signal that regulates etioplast and chloroplast development during extended periods of darkness.

This study evaluates the in vitro activity of β-lactamase inhibitors relebactam and vaborbactam with β-lactams against MABC clinical isolates, showing improved anti-MABC activity.

This study shows that MSL1, MSL2, and MSL3 interact genetically and physically, suggesting inter-organellar communication is important for plant development.