J. Li

The paper shows that SARS-CoV-2 exhibits substantial within-host genetic diversity, challenging the assumption of low diversity per infected individual and highlighting the importance of studying evolution within hosts.

This paper identifies that NS5A of CSFV inhibits NF-κB signaling by degrading NEMO and blocking its k63-linked polyubiquitination.

This study shows that WWP1 deficiency protects against cardiac remodeling and function decline caused by simulated microgravity in mice.

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

This study shows that IGF-1C and P24 together enhance osteogenic differentiation of BMSCs by activating p38 and JNK pathways.

This study shows that BSCL2 deficiency in the heart causes heart failure through excessive lipid catabolism, reduced energy reserves, and ATP levels, which can be mitigated by inhibiting fatty acid oxidation or high-fat diet.

This study uses deep metagenomics to explore microbial communities in Challenger Deep sediment, revealing new MAGs, metabolic functions, and virus-host interactions in hadal zone ecosystems.

This study shows that delivering a childhood vaccine antigen via attenuated Listeria improves immunotherapy for pancreatic cancer by converting cold tumors into hot tumors and enhancing T cell activity.

This study shows that xanthan gum, a common food additive, promotes the adaptation of the human gut microbiota by enabling a novel degradation pathway in an uncultured Ruminococcaceae bacterium and facilitating cross-feeding by Bacteroides species.

This paper identifies aCPSF1 and terminator U-tract synergy in archaeal transcription termination, showing their roles in determining termination efficiency through KH domain binding and nuclease activity.

The paper identifies metabolic reprogramming in platinum-resistant cancer cells from glycolysis to fatty acid uptake and beta-oxidation, showing a correlation with resistance and proposing a treatment strategy.

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

The paper introduces an enhanced sampling method for protein-ligand binding with induced fit, validated on ADPr and MacroD1/MacroD2 complexes, showing accurate free energy predictions and structural changes.

The paper examines the relationship between mangrove forest fragmentation and salt marsh invasion magnitude across a climatic gradient in southeast China.

This study investigates salt-induced structural transitions in the DNA-interacting protein SSB using magnetic tweezers and infrared spectroscopy, revealing discontinuous thermodynamic behavior at binding mode transitions.

The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.

This study assesses changes in undergraduate student interest in healthcare careers during the COVID-19 pandemic using a survey of 297 students, finding increased interest despite pandemic challenges.

This pre-clinical study evaluates the safety and efficacy of clinical-grade human iPSC-derived cardiomyocyte patches in treating heart failure, showing improved cardiac function and no adverse effects.

This study identifies EgGLUT1 as a critical gene for glucose uptake in Echinococcus granulosus s.l. larvae, showing that inhibiting it reduces parasite viability and cyst formation in mice.

This study identifies and validates SARS-CoV-2 CD8+ T cell epitopes, demonstrates their cross-presentation, and shows the efficacy of peptide vaccines in transgenic mice.

The paper investigates the role of the PARP1/NAD+/SIRT6 axis in modulating the assembly and disassembly of DNA repair protein complexes during base excision repair.

This paper evaluates the reliability and reproducibility of methods for measuring mitochondrial respiration and citrate synthase activity in human skeletal muscle, identifying technical and biological variability factors.

This study develops a genetic toolbox for Prevotella copri to investigate polysaccharide utilization systems and identifies diet-associated PULs.

The paper identifies a novel SARS-CoV-2-related bat virus, PrC31, with complex recombination events and partial genetic similarity to SARS-CoV-2.

This study examines how Saccharina japonica and Sargassum horneri respond to ocean acidification and eutrophication, finding that S. horneri has competitive advantages under combined stress.

This study examines how broccoli sprout sulforaphane affects hemodynamics and aortic myogenic contractions in mice consuming saline water.

This study measures the toughness and critical length scales of human blood clots using a modified lap-shear method, finding toughness independent of geometry and loading conditions.

The paper identifies novel bat coronaviruses, including relatives of SARS-CoV-2, from a region in China, providing insights into their evolutionary origins and geographic distribution.

This study shows that norUDCA induces bile flow and bicarbonate secretion in mice without requiring ASBT or OST, suggesting these transporters are not directly involved in its choleretic actions.

This study identifies RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma, showing its overexpression correlates with poor survival and that its inhibition reduces tumor growth and overcomes chemoresistance.