J. Li

The paper identifies ESCRT-0 as a mediator of selective microautophagy of ubiquitylated proteasomes under low glucose conditions in yeast.

This study identifies JM03, a crotamiton derivative, as a small molecule that extends C. elegans lifespan and improves stress resistance by inhibiting OSM-9 and activating SKN-1 signaling.

This study shows that a single amino acid substitution in mouse protamine 1 disrupts DNA packaging and causes infertility by altering protein function and developmental outcomes.

This study shows ICOS costimulation is essential for Tfr cell differentiation during GC reactions and highlights their role in immune tolerance.

The paper investigates how vegetation structure influences soil cyanobacterial communities across soil development in global biomes, finding stable communities in most cases but shifts during vegetation transitions.

This study shows that unsaturated lipids reduce renal damage in diabetes by increasing lipid storage and protecting against ER stress in proximal tubular cells.

The paper develops a 1,2-dicarbonyl compound that selectively activates Nrf2 at sites of oxidative stress, reversing pain in mice and offering a targeted approach for treating oxidative stress-related disorders.

This study identifies genomic diversity and degradation pathways for N,N-dimethylformamide (DMF) by analyzing 20,762 genomes, revealing plasmid-mediated degradation and anaerobic potential for methane production.

This paper develops a cellulose-based method using nanobodies to capture and neutralize SARS-CoV-2 pseudoviruses, showing effectiveness against wildtype and D614G variants.

The paper identifies convergent amino acid replacements in multiple chloroplast genes across C4 grasses, showing higher molecular convergence in C4 lineages compared to C3 lineages.

This study examines the environmental impact of administrative division adjustments on Chaohu Lake using a quasi-natural experiment and synthetic control method, finding mixed effects on water quality indicators.

This study uses iTRAQ-based proteomics to identify cold stress-responsive proteins in japonica rice seedlings, finding 289 regulated proteins involved in photosynthesis and metabolism.

The paper develops a high-throughput method to measure protein interaction affinity without purification, applied to SUMO E2/E3 enzymes and substrates, revealing co-recognition and affinity mechanisms.

This study shows citrus Huanglongbing is an immune-mediated disease caused by CLas, where ROS-induced cell death in phloem tissues can be mitigated by antioxidants and gibberellin, reducing disease symptoms.

This paper develops a non-invasive imaging technique using NIR-IIc light to image deep tissues in mice, achieving imaging depths of ~800 m and visualizing immune structures in lymph nodes.

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

This study investigates how hyperproteinemia disrupts blood cell homeostasis in an invertebrate model, identifying novel signaling pathways and potential biomarkers.

The paper develops new statistics to detect Dobzhansky-Muller incompatibilities in hybrid populations by analyzing haplotype frequency imbalances, identifying new DMI candidates in swordtail fish.

This study identifies three conserved hydrophobic residues in the CC domain of rice NLR Pit that contribute to plasma membrane localization and immune induction, distinct from their roles in other NLRs.

This study investigates how confined environments influence biofilm morphology and cell ordering in Vibrio cholerae using single-cell imaging and biomechanical analysis.

The paper measures ligand-binding kinetics of integrin states and finds low-affinity states bind faster than the high-affinity state.

This paper develops solvent shift assays to assess target engagement using quantitative proteomics, showing they can identify compound targets and serve as a reliable alternative to existing methods.

This study identifies R2R3-MYB transcription factors in C. sinensis and links some to the regulation of galloylated catechin biosynthesis.

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

This paper introduces a CRISPR-nCas3 system for efficient genome editing in bacteria, enabling high-efficiency deletion of large genomic regions.

This study shows SAFA interacts with antiviral RNAs to open chromatin and enhance immune gene expression during viral infection.

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

This study establishes three clinical breakpoint values for danofloxacin against Glaesserella parasuis using epidemiological, pharmacodynamic, and clinical data.

This study evaluates the synergistic interaction of CaD23 with antibiotics and identifies its membrane-permeabilizing mechanism through experimental and molecular dynamics simulations.

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.