This study identifies TFR1, SAHH, and HV307 as potential biomarkers for colorectal cancer screening through proteomics analysis of pre-cancerous to cancerous tissues.

bioRxiv · Oct 19, 2020Biochemistry

A multi-omic cohort as a reference point for promoting a healthy human gut microbiome

Z. Jie, S. Liang, Q. Ding, F. Li, S. Tang, D. Wang, Y. Lin, P. Chen, K. Cai, X. Qiu, Q. Li, Y. Liao, D. Zhou, H. Lian, Y. Zuo, , X. Xu

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

bioRxiv · Nov 8, 2019Microbiology

Protein profiling reveals the characteristic changes of complement cascade pathway in the tissues of gastric signet ring cell carcinoma

Y. Fan, B. Bai, Y. Ren, Y. Liu, F. Zhou, X. Lou, J. Zi, G. Hou, Q. Zhao, S. Liu

This study uses proteomics to identify complement cascade pathway changes in gastric signet ring cell carcinoma tissues compared to adjacent regions and adenocarcinomas.

bioRxiv · Oct 23, 2019Cell Biology

Life history recorded in the vagino-cervical microbiome

Z. Jie, C. Chen, L. Hao, F. Li, L. Song, X. Zhang, J. Zhu, L. Tian, X. Tong, K. Cai, Y. Ju, X. Yu, Y. Li, H. Zhou, H. Lu, , H. Jia

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

bioRxiv · Sep 4, 2019Microbiology

Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics

H. Zhong, H. Ren, Y. Lu, C. Fang, G. Hou, Z. Yang, B. Chen, F. Yang, Y. Zhao, Z. Shi, B. Zhao, J. Wu, H. Zou, J. Zi, J. Chen, , J. Li

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

bioRxiv · Jun 12, 2019Microbiology