L. Deng

This study identifies a novel Ig-like fold in bacterial adhesins that binds human CEACAM receptors, suggesting a broad mechanism for bacterial pathogenesis.

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

This study shows that fecal filtrate transfer prevents necrotizing enterocolitis in preterm pigs without side effects, while fecal microbiota transplantation does not.

This study shows that cell-ECM interactions in the fluidic phase determine epithelial structure topology and polarity through ECM topology and biomechanical cues.

This study engineers Yarrowia lipolytica to produce squalene by optimizing the mevalonate pathway, achieving a 28-fold increase in squalene yield.

The paper shows MDCK cells coordinate collagen I fiber assembly through motion, promoting branching morphogenesis, with cell contraction and actin cytoskeleton playing key roles.

This study compares protein and peptide fractionation methods for proteome analysis in yeast, finding that FASP-HpH provides the highest protein identification when using a high-resolution mass spectrometer.

The paper shows that lung type II alveolar epithelial cells induce IFN-beta and recruit CCR2+ monocytes to combat vaccinia virus infection.

This study shows cells can sense long-range biomechanical forces through the matrix to initiate distant mechanical communication, enabling coordinated self-assembly.

This study identifies fibrinogen binding and iron acquisition as key determinants of MRSA vaginal colonization using a mouse model and transcriptomic analysis.

This study characterizes the vaginal DNA virome in patients with non-female factor infertility and finds associations between viral community composition and bacterial dysbiosis.

BiasDB compiles and analyzes known biased GPCR ligands, offering a resource for medicinal chemistry and pharmacology.

This study compares biodegradable mulch film with polyethylene plastic film in cotton and maize, finding higher yield and water use efficiency with biodegradable film without residual pollution.

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

This study adapts base editors to Streptomyces, achieving high-efficiency genome editing without DNA double-strand breaks.

This paper engineers an acetyl-CoA metabolic shortcut in Yarrowia lipolytica to efficiently produce triacetic acid lactone from acetic acid, achieving a 8.5-fold increase in titer and 31.9% of theoretical yield.

The paper investigates the effectiveness of microbial coalbed methane enhancement in the Qinshui Basin, showing increased methane production through biogasification in specific wells.

The paper shows mitotic CDK promotes replisome disassembly, fork breakage, and complex DNA rearrangements via TRAIP-dependent ubiquitylation of CMG helicase.

The paper studies the yeast chromosome-segregation system using electron cryotomography and perturbations, revealing the structure and dynamics of kinetochore-microtubule interactions.