L. Zhao

This study develops an in vitro cell culture model of BKPyV persistence, showing that random genome recombination can enhance viral replication.

This study compares the in vitro efficacy of four oxazolidinones against rapid-growing Mycobacteria isolates from Beijing, finding tedizolid most effective against M. abscessus and delpazolid against M. fortuitum.

This study identifies genetic transcript regulation and cyclohexane release as factors enhancing duckweed regeneration through callus formation.

This study identifies a γδ IEL hyperproliferative phenotype influenced by the intestinal microbiota, which enhances protection against bacterial infection.

This study analyzes mosquito species and viromes in Wuhan, China, from April to October 2020, revealing seasonal changes and stable viruses in Culex mosquitoes.

The paper identifies and characterizes the subunit organization of the C1b projection in the central apparatus of cilia, revealing its role in regulating dynein activity and ciliary beating.

This study reports the cryo-EM structure of PTH2R bound to TIP39 and a Gs protein, revealing ligand specificity and disease-associated mutation effects.

The paper identifies and characterizes five hydroxypyruvate reductase genes in Chlamydomonas, revealing distinct enzymatic activities, subcellular locations, and roles in photorespiration.

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

This study uses transcriptomes and genome data to resolve phylogenetic relationships and detect whole-genome duplication in Theaceae, finding a WGD event and introgression events.

This study uses fMOST and scRNA-seq to map the spatial and cellular distribution of rabies virus in the mouse brain, revealing infection in multiple nuclei and non-neuronal cells.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

The paper develops patient-derived xenografts and organoids for breast cancer to enable drug screening and precision oncology, showing efficacy of an FDA-approved drug in a clinical case.

This study identifies C28 as a compound that modulates IKs channel voltage sensor activation, reversing drug-induced APD prolongation without affecting normal APD.

This study develops a qPCR assay to measure Klebsiella colonization density in rectal swabs and finds that higher density is significantly associated with increased infection risk.

The paper investigates how intermolecular interactions influence protein adaptation and co-adaptation across species and populations.

The paper identifies an immune gene signature linked to MGMT methylation in glioblastoma that predicts prognosis and immune response.

This study shows prior SARS-CoV-2 infection in golden hamsters provides partial protection but not sterilizing immunity, and virus can still be transmitted between infected and naive animals through direct contact.

This paper investigates the role of apolipoprotein M in anthracycline cardiotoxicity, finding that ApoM protects against cardiac dysfunction and lysosomal injury through the autophagy-lysosome pathway.

The paper identifies a suppressor mutation that compensates for SRP loss by slowing translation and reducing fidelity, allowing correct protein targeting in E. coli.

This study shows HBV envelope proteins are present on the host cell plasma membrane and can be targeted by T-cells for therapeutic purposes.

The paper models how traits in microbial communities evolve under eco-evolutionary dynamics by integrating population genetics with resource-mediated dynamics.

The paper shows that gene age and tissue specificity differ between male and female Drosophila gonads, with older genes being more ovary-biased and younger genes more testis-biased.

This study investigates the role of the BMPR-II-SMAD3/MRTF complex in ASMC proliferation and migration in asthma, finding it contributes to airway remodelling.

This study examines sex-specific effects of uteroplacental insufficiency-induced low birth weight on hepatic cholesterol metabolism in adult guinea pigs, finding increased cholesterol and altered gene expression in males but not females.

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

This study investigates the evolutionary basis of Drosophila suzukii's egg-laying behavior by combining behavioral, genomic, and gene expression analyses with closely related species.

The paper investigates cross-reactivity between mugwort and house dust mite allergens, finding that mugwort tropomyosin induces a non-Th2 response in allergic rhinitis patients.

This study develops and characterizes high-affinity mouse monoclonal antibodies against SARS-CoV-2, showing their neutralizing and diagnostic potential.