L. Zhao

This study shows EGCG protects against radiation-induced intestinal injury by preserving macrophages and gut microbiota, reducing inflammation and improving survival in mice.

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

The paper identifies over 1000 unannotated open reading frames with protein evidence in Drosophila, revealing diverse evolutionary patterns and frequent turnover of de novo proteins.

The paper shows that hypoxia induced by pinewood nematode (PWN) loading increases tracheal elasticity and ECM thickness in beetles, enhancing PWN transmission.

This study implants graphene quantum dots in PEGylated nanoparticles to enhance in vivo imaging and tumor detection, showing improved circulation and tumor accumulation.

The paper shows that ITE, an AHR agonist, enhances PD1 antibody efficacy in a glioma model by reducing MDSCs and increasing CD8+ T cell infiltration.

This study identifies tryptamine, a gut microbiota-derived metabolite, as a contributor to insulin resistance in type 2 diabetes through TAAR1-ERK signaling.

This study identifies Ruminococcus gnavus as a gut bacterium that contributes to IBS-D by increasing serotonin biosynthesis through phenethylamine production.

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

This study infects neonate and adult mice with dengue virus via the nasal route, showing viral tropism and replication in multiple tissues, suggesting respiratory transmission as a potential non-vector route.

This study shows Arbidol inhibits esophageal squamous cell carcinoma growth by targeting the ATR kinase and disrupting the DNA replication pathway.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

This paper evaluates click chemistry-based methods for cross-linking peptide enrichment, finding that acid-cleavable protein-based conjugation identifies the most cross-linked peptides.

This study maps chromatin reprogramming and transcriptional regulation during hexaploid wheat embryogenesis, revealing epigenetic mechanisms governing cell fate and organogenesis.

This paper introduces SPACX, a method to profile protein conformation and interactions in living cells, revealing subcellular-specific heterogeneity and functional differences in PTEN.

This study develops allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv, showing enhanced anti-HIV activity in vitro compared to autologous CAR-T cells.

The paper shows that parasite-induced limb movements in male frogs enhance the attractiveness of acoustic signals by incorporating visual elements, influencing female mate choice.

The paper determines the near-atomic structure of the Saccharomyces cerevisiae nuclear pore complex inner ring, revealing its assembly and functional dynamics.

This study investigates age-related changes in mutation rates and gene expression in Drosophila germline cells, finding distinct mutational biases and increased post-meiotic gene expression in older flies.

The paper identifies CAD-induced pyrimidine synthesis and ribosomal biogenesis as critical for rapid recall responses in memory CD8+ T cells.

The paper examines how dominant species influence ecosystem stability across different spatial scales in Inner Mongolian grassland, finding that stability is linked to dominant species dynamics and precipitation patterns.

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.

This study determines the cryo-EM structure of VAR2CSA and its complex with CSA, revealing conformational changes and identifying mutations that abolish CSA binding and cytoadherence to placental and tumor cells.

The paper identifies SeASF1 and SeH4 as regulators of the PI3K/AKT pathway in filamentous ascomycete, influencing sexual and asexual development through interactions with SeDJ-1 and SePI3K.

This study shows that human cord blood-derived stem cells suppress B-cell activation via a Gal-9-dependent cell contact mechanism and affect calcium levels and signaling pathways.

This study shows that cannabis vapor exposure in adult male mice reduces sperm count and motility in F0 and F1 generations but not F2, and disrupts spermatogenesis and DNA methylation in F1 testes.

This study shows that deleting STAT3 in stromal cells prevents kidney fibrosis by blocking pericyte trans-differentiation and migration.