Prebiotically Plausible ‘Patching’ of RNA Backbone Cleavage Through a 3′-5′ Pyrophosphate Linkage
T. H. Wright, C. Giurgiu, A. Radakovic…·J. W. Szostak
This study demonstrates that 3′-phosphate terminated RNA strands can participate in template-directed copying reactions to form stable pyrophosphate linkages, offering a non-enzymatic pathway for RNA strand recovery.