L. Zhou

The paper develops a nanopore sequencing method to identify STIs and detect antimicrobial resistance in clinical samples.

This study shows that combining CDK4/6 and HSP90 inhibitors reduces HIF1 expression and cancer cell viability, including in Rb-deficient cells.

The paper develops a droplet printing method to study bacterial ecology by manipulating spatial arrangements of E. coli strains and shows how micron-scale structure affects competition and coexistence.

The paper shows that rapid apoptosis in Aedes aegypti midgut cells limits DENV-2 and ZIKV proliferation, suggesting apoptosis as an antiviral defense mechanism.

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

This study shows vitexin inhibits melanoma cell invasion and metastasis by targeting the STAT3 signaling pathway.

This study identifies lncRNA-RMST as a SOX2 co-regulator that modulates miR-1251 expression, influencing cell proliferation and migration in Hirschsprung's disease.

This study shows MEK inhibitors reduce ACE2 and inflammatory cytokines, enhance NK cell activity, and block SARS-CoV-2 pseudovirus infection in human cells.

This paper develops a numerical model to simulate bleb formation and evolution in cells, showing how parameters affect bleb size and shape.

The paper identifies two types of plant cysteine oxidases (PCOs) and shows that both are required to regulate the anaerobic response in Arabidopsis, with B-type PCOs acquiring hypoxia inducibility in spermatophytes.

The paper tests the growth rate hypothesis by subjecting zooplankton populations to selection for fast population growth under phosphorus-rich and phosphorus-poor conditions, showing context-dependent evolutionary responses.

The paper investigates the ability of Arhopalus rusticus to transmit pine wood nematodes, finding that 12 beetles can transmit the nematodes through feeding on pine needles.

This study shows ACE2 and TMPRSS2 are expressed on human ocular surface cells, suggesting they can be infected by SARS-CoV-2.

This study shows that ACE2-overexpressed mesenchymal stem cells improve cardiac function and reduce fibrosis in a rat myocardial infarction model.

This study identifies B-plexins as critical for mechanosensing in epidermal stem cells, linking mechanical feedback to cell division control during development and in cancer.

The paper identifies sex differences in CD8+ T cell programming in bladder cancer, showing male-biased T cell exhaustion and implications for immune checkpoint therapy.

This paper develops a machine learning pipeline for segmenting subcellular structures from cryo-electron tomograms, using supervised and semi-supervised techniques to improve segmentation accuracy.

The paper uses protein-proofed single-cell RNA profiling to identify tissue cells vulnerable to SARS-CoV-2 infection across 36 tissues, revealing lung and cardiac cells as top targets.

This study evaluates genomic predictive ability for wood properties in Norway spruce, finding that using 80-90% of data as training sets yields high accuracy, and that predicting young trees from older coring data is feasible.

This study shows that SARS-CoV-2 nucleocapsid protein reduces pluripotency in human iPSCs, causing them to lose differentiation ability and adopt fibroblast-like morphology.

The paper investigates how increased replication of DNRA bacteria in anammox bioreactors reduces nitrogen removal capacity by out-competing anammox bacteria.

This paper develops a low-cost DNA-based platform for rapid and sensitive detection of viral RNA, demonstrating its effectiveness with Zika and SARS-CoV-2 as model systems.

This study investigates how the feeding behavior of Monochamus alternatus affects the departure of pine wood nematodes, finding no significant difference but linking increased motility and oxidative phosphorylation to nematode departure.

This study develops an anti-somatostatin receptor 2 antibody-drug conjugate (ADC) that effectively targets and kills neuroendocrine tumors with minimal toxicity.

This study investigates how RNA could emerge from prebiotic mixtures of ribonucleotides, arabinonucleotides, and 2'-deoxyribonucleotides through nonenzymatic template-directed synthesis.

The paper identifies and characterizes lncRNAs in maize, finding that many are derived from transposable elements and play regulatory roles in abiotic stress responses.

This paper describes a method to assemble multi-specific antibodies using DNA-mediated assembly, showing efficacy in tumor cell cytotoxicity and xenograft suppression.

This study demonstrates non-enzymatic RNA primer extension through strand displacement using short RNA oligonucleotides, suggesting a prebiotic mechanism for RNA replication.

The paper examines how antiretroviral therapy affects cholesterol biosynthesis in HIV-positive individuals, finding upregulated HMGCR and ABCA1 expression and dysregulation in SREBP-2 and LDLR pathways.