M. Xu

This paper identifies six broad-spectrum inhibitors of SARS-CoV-2 and MERS-CoV spike-mediated cell entry through drug repurposing screens using pseudotyped particles.

This paper describes a method for expressing and purifying full-length human FMRP, FXR1P, and FXR2P from E. coli with high yields and purity.

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.

The paper identifies six autophagy modulators that block SARS-CoV-2 cytopathic effects in Vero-E6 cells with EC50 values between 2.0 and 13 µM.

This study compares clinical characteristics and prognosis of second primary non-small cell lung cancer after cervical cancer with first primary non-small cell lung cancer using SEER data.

The paper identifies the proteasome as critical for ZIKV and DENV replication through three systems biology approaches and finds proteasome inhibitors suppress both viruses.

This study identifies altered B cell subset homeostasis in IgAV patients, with increased plasmablasts and decreased specific memory B cells, correlating with IgA levels.

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.

This study links cellular virological stages in chronic hepatitis B to liver fibrosis progression through spatial and functional analysis of viral and host gene expression.

This paper identifies SPOCK1 as a promoter of breast cancer progression by interacting with SIX1 and activating the AKT/mTOR pathway, suggesting it as a potential therapeutic target.

This meta-analysis evaluates carbon nanoparticles' effectiveness in improving lymph node detection and protecting parathyroid glands during thyroidectomy, finding increased lymph node harvest and reduced parathyroid complications.

This study compares the gut microbiome of short-term and long-term medical workers to normal controls, finding significant structural changes linked to hospital exposure.

The paper investigates the genetic architecture of signal-preference coevolution in Laupala crickets, finding strong genetic coupling between male pulse rate and female preference loci.

The paper provides length-weight relationships for 17 fish species in the Luanhe River Estuary, finding slope values ranging from 2.572 to 3.6581.

This study identifies iRhom2 as a key regulator that promotes obesity-associated metabolic disorder by enhancing adipose inflammation and insulin resistance.

This study shows AcrIIA2 and AcrIIA2b inhibit Cas9 DNA binding through structural occlusion, with temperature-dependent effects due to structural and environmental differences.

The paper studies the distribution and characteristics of floating Zostera marina clumps in Bohai Bay, China, and notes their ecological importance as habitats for marine species.

This paper develops a novel MDS patient-derived xenotransplantation model in MISTRG mice that faithfully represents all MDS subtypes and enables effective drug testing.

This study identifies a soluble form of syntaxin 3 that functions as a transcription regulator in the nucleus, influencing gene expression and promoting cell proliferation in breast cancer.

This study presents a method for 3D morphological reconstruction and force inference in early C. elegans embryos, showing deviations of 7% and 10% from force balance and Young-Laplace relations.

This study identifies c-Maf-dependent regulatory T cells that suppress inflammation caused by the pathobiont Helicobacter hepaticus, preventing colitis in mice.