M. Zhao

This study identifies early urinary biomarkers in a rat model of multiple sclerosis and shows that early treatment with methylprednisolone reduces disease incidence.

This study identifies WDR5 as an epigenetic regulator that promotes breast cancer growth and metastasis through KMT2-independent translation regulation, suggesting therapeutic strategies targeting WDR5.

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

This paper introduces a heat-shock protocol for wheat transformation that significantly improves efficiency using BBM-WUS, reducing the time to obtain transgenic plants to 60 days.

This study shows that M2 macrophage-derived extracellular vesicles reduce cytokine storm by targeting multiple pathways and can act as nanodecoys against SARS-CoV-2.

The paper shows that differences in peptide binding between chicken MHC class I alleles BF2*1901 and BF2*1501 explain their differing susceptibility to Mareks disease.

This study identifies two phosphonate biosynthetic gene clusters in Pantoea species causing onion pathogenicity, with the novel Halophos cluster contributing to necrosis.

The paper analyzes chromatin landscapes of Th17 cell subsets to uncover regulatory mechanisms driving their heterogeneity and identifies BACH2 as a novel regulator of pathogenicity.

This study quantifies how anatomical traits of Coffea arabica leaves influence photosynthesis using correlation and path analysis, identifying leaf thickness and stomatal density as key factors.

This paper reconciles avian species names in GenBank with standardized eBird/Clements taxonomy to improve linkage between phylogeny and phenotype data.

The paper identifies a new intercellular spread mode of RSV that is virion-independent and antibody-insensitive, contributing to immune escape and viral persistence.

This study identifies Beauvericin as an activator of dendritic cells via the TLR4 signaling pathway, suggesting its potential as a vaccine adjuvant or cancer immunotherapy.

This study shows that electrochromic windows reduce pathogen growth and viability on surfaces through blue light exposure.

This study compares immune responses between BioNTech and Sinovac vaccines in Hong Kong, finding Sinovac induces lower neutralizing antibodies and wanes faster against SARS-CoV-2 variants.

The paper shows that changes in the MPER of HIV-1 Env lead to premature triggering and increased neutralization sensitivity, which can be counteracted by distant State 1-stabilizing Env modifications.

This paper isolates and characterizes five sterols from Laminaria japonica and evaluates their anti-inflammatory and antioxidant activities through enzyme inhibition and molecular docking.

The paper develops SSR markers from drought stress-responsive miRNAs in Dongxiang wild rice and verifies their genetic diversity across DXWR and modern rice varieties.

This study uses computational modeling to show neonatal collateral arteries are more effective than adult ones in restoring blood flow during heart regeneration.

This paper introduces CARM, a CRISPR-Cas-based method for whole-genome mutagenesis, and demonstrates its application in evolving yeast strains for increased beta-carotene and S-adenosyl-L-methionine production.

The paper identifies specialized innate-like T cells and dendritic cells that contribute to protection against pneumococcal lung infection through specific cytokine production and cellular interactions.

The paper identifies MK-derived immune-stimulating cells (MDICs) that enhance host defense against bacterial infections by interacting with myeloid cells and producing cytokines.

The paper investigates miR-384's role in regulating Reelin by inhibiting ADAMTS4 in neuronal cell lines, showing reduced ADAMTS4 and Reelin fragments with miR-384 overexpression.

This paper shows how actin polymerization dynamics integrate subcellular and cellular-scale guidance cues to direct cell migration.

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

This study reports cryo-EM structures of Ubr1 complexes to elucidate the mechanism of ubiquitination initiation and elongation using a single E2 enzyme.

This study identifies ultrapotent bispecific antibodies that neutralize emerging SARS-CoV-2 variants by targeting multiple spike protein regions, showing efficacy in vitro and in a hamster model.

This study identifies NPR1 and EDS1 as interacting coactivators that synergistically activate PR genes and plant defenses through Mediator complex recruitment and mutual stabilization.

This study shows that Withaferin A promotes white adipose browning and prevents obesity by activating the Prdm16-FATP1 pathway via the sympathetic nervous system.

This study presents cryo-EM structures of human p97 complex with and without inhibitor NMS-873, revealing conformational changes and allosteric inhibition mechanisms.